beta2-Microglobulin Native Protein
beta2-Microglobulin, B2M Protein (Active)
Applications
ELISA
Purity
>90% by SDS-PAGE
Synonyms
beta2-Microglobulin; N/A; beta2-Microglobulin, B2M Protein (Active); Beta-2-microglobulin; B2M; CDABP0092; HDCMA22P; beta2-Microglobulin native protein
Host
Human tissue
Purity/Purification
>90% by SDS-PAGE
Form/Format
Liquid; Each vial contains 10 mM PBS (pH 7.4).
Applicable Applications for beta2-Microglobulin native protein
ELISA
Storage Buffer
Each vial contains 10 mM PBS (pH 7.4).
Preparation and Storage
Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
Avoid repeated freeze and thaw cycles.
Related Product Information for beta2-Microglobulin native protein
Purified human beta2-Microglobulin protein.
Background: Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. B2M gene contains 4 exons and spans approximately 8 kb. The neonatal Fc receptor (FcRn) is a heterodimer of a nonclassical MHC class I alpha and B2M that binds the 2 most abundant serum proteins, IgG and albumin, after their constitutive cellular uptake. FcRn binds both proteins, thus acting as a salvage pathway, protecting them from lysosomal degradation and extending the catabolic half-lives of both proteins. Beta-2-microglobulin had been found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease, cadmium poisoning, and other conditions leading to renal tubular dysfunction.
Background: Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. B2M gene contains 4 exons and spans approximately 8 kb. The neonatal Fc receptor (FcRn) is a heterodimer of a nonclassical MHC class I alpha and B2M that binds the 2 most abundant serum proteins, IgG and albumin, after their constitutive cellular uptake. FcRn binds both proteins, thus acting as a salvage pathway, protecting them from lysosomal degradation and extending the catabolic half-lives of both proteins. Beta-2-microglobulin had been found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease, cadmium poisoning, and other conditions leading to renal tubular dysfunction.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
beta2-microglobulin
Similar Products
Product Notes
The beta2-Microglobulin (Catalog #AAA59064) is a Native Protein produced from Human tissue and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's beta2-Microglobulin can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the beta2-Microglobulin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "beta2-Microglobulin, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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