Igf2r recombinant protein

Recombinant Human Igf2r Protein (hFc Tag), HPLC-verified

Cat. Num. AAA259196

• Purity: >= 95% as determined by SDS-PAGE.; = 95% as determined by SEC-HPLC.
• Synonyms: Igf2r; N/A; Recombinant Human Igf2r Protein (hFc Tag), HPLC-verified; insulin like growth factor 2 receptor; CI-M6PR Protein, Human; CIMPR Protein, Human; Igf2r recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >= 95% as determined by SDS-PAGE.; = 95% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile PBS, pH 7.4.; Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

• Species: Human
• Predicted N Terminal: Gln 41
• Endotoxin: <1.0 EU per ug of the protein as determined by the LAL method
• Protein Construction: A DNA sequence encoding the Human Igf2r (P11717)(Met1-Asp1365) was expressed with the Fc region of human IgG1 at the C-terminus.
• Activity: Immobilized Recombinant Human TROP2/TACSTD2 Protein (His Tag) at 2 ug/mL (100 uL/well) can bind Recombinant Human Igf2r Protein (Fc Tag) , with a linear range of 0.16-4.0 ug/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Application Data

(Immobilized Recombinant Human TROP2 / TACSTD2 Protein (His Tag) (Cat: 10428-H08H) at 2 ug/mL (100 uL/well) can bind Recombinant Human Igf2r Protein (Fc Tag) (#AAA259196) , with a linear range of 0.16-4.0 ug/mL.)

Application Data

Application Data

Related Product Information for Igf2r recombinant protein

Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth, survival, migration and differentiation. The type 2 IGF receptor (IGF2R) modulates circulating and tissue levels of IGF2 by targeting it to lysosomes for degradation. The extracytoplasmic region of IGF2R has three binding sites: one for IGF2 in domain 11 and two for Man-6-P in domains 3, 5 and 9. Binding between IGF2 and IGF2R induces the lysosomal degradation of IGF2. IGF2R serves to clear IGF2 from the circulation or degrade excess circulating IGF2. Soluble IGF2R can affect the size of some organs exclusively by reducing the biological activity of IGF2.

References

Bella P, et al. (2020) Blockade of igf2r improves muscle regeneration and ameliorates duchenne muscular dystrophy. EMBO Mol Med 12 (1): e11019.