Application Data
IL-13 R alpha 2/IL13RA2 Recombinant Protein | IL-13Ralpha2/IL13RA2 recombinant protein
IL-13 R alpha 2/IL13RA2 Protein, Human, Recombinant (ECD, hFc Tag), HPLC-verified
Gene Names
IL13RA2; CT19; IL-13R; IL13BP; CD213A2
Purity
>= 90% as determined by SDS-PAGE.= 95% as determined by SEC-HPLC.
Synonyms
IL-13 R alpha 2/IL13RA2; N/A; IL-13 R alpha 2/IL13RA2 Protein, Human, Recombinant (ECD, hFc Tag), HPLC-verified; interleukin 13 receptor, alpha 2; CD213A2 Protein, Human; CT19 Protein, Human; IL-13R Protein, Human; IL13BP Protein, Human; IL-13Ralpha2/IL13RA2 recombinant protein
Host
CHO cells
Purity/Purification
>= 90% as determined by SDS-PAGE.
= 95% as determined by SEC-HPLC.
= 95% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Human
Predicted N Terminal
Asp 27
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Human IL13Ra2 (NP_000631.1)(Met1-Arg343) was expressed with the Fc region of human IgG1 at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for IL-13Ralpha2/IL13RA2 recombinant protein
Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High-Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Ralpha2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Ralpha2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Ralpha2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.
References
Zhou G, et al.. (2005) Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 79(9): 5272-7.
Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
Nair BG, et al.. (2011)
Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5
Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
Nair BG, et al.. (2011)
Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,176 Da
NCBI Official Full Name
interleukin-13 receptor subunit alpha-2
NCBI Official Synonym Full Names
interleukin 13 receptor, alpha 2
NCBI Official Symbol
IL13RA2
NCBI Official Synonym Symbols
CT19; IL-13R; IL13BP; CD213A2
NCBI Protein Information
interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain
UniProt Protein Name
Interleukin-13 receptor subunit alpha-2
UniProt Gene Name
IL13RA2
UniProt Synonym Gene Names
IL13R; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2
UniProt Entry Name
I13R2_HUMAN
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Product Notes
The IL-13Ralpha2/IL13RA2 il13ra2 (Catalog #AAA259175) is a Recombinant Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-13 R alpha 2/IL13RA2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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