IL-17RC Fc tagged Recombinant Protein | IL17RC recombinant protein
Human IL-17RC Fc tagged Recombinant
Purity
>98%, as determined by SDS-PAGE and HPLC
Synonyms
IL-17RC Fc tagged; N/A; Human IL-17RC Fc tagged Recombinant; Human IL-17RC Fc tag Recombinant; il-17rc; il17Rc; interleukin-17 r; IL17RC recombinant protein
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant Interleukin-17RC is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Sequence Length
707
Host Note
Optimized DNA sequence encoding extracellular domain of human IL-17RC receptor including a C terminal Human IgG1 Fc tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant IL17RC-Fc is a homodimer protein consisting of 675 amino acid residue subunits, due to glycosylation migrates as an approximately 100kD protein under reducing SDS-PAGE conditions.
Preparation and Storage
Recombinant IL-17RC, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Related Product Information for IL17RC recombinant protein
IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites. Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.
Product Categories/Family for IL17RC recombinant protein
References
• il-17a and IL-17RC expression in the macula of the human eye with age-related macular degeneration .Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 1667.
• il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by il-17ra and IL-17RC rna interference in rheumatoid synoviocytes .Ann Rheum Dis, Feb 2011; 70: 341 - 348.
• IL-17RC is required for immune signaling via an extended sef/il-17r signaling domain in the cytoplasmic tail .J. Immunol., Jul 2010; 185: 1063 - 1070.
• IL-17RC is required for il-17a– and il-17f–dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis .J. Immunol., Apr 2010; 184: 4307 - 4316.
• the human il-17f/il-17a heterodimeric cytokine signals through the il-17ra/IL-17RC receptor complex .J. Immunol., Aug 2008; 181: 2799 - 2805.
• il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by il-17ra and IL-17RC rna interference in rheumatoid synoviocytes .Ann Rheum Dis, Feb 2011; 70: 341 - 348.
• IL-17RC is required for immune signaling via an extended sef/il-17r signaling domain in the cytoplasmic tail .J. Immunol., Jul 2010; 185: 1063 - 1070.
• IL-17RC is required for il-17a– and il-17f–dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis .J. Immunol., Apr 2010; 184: 4307 - 4316.
• the human il-17f/il-17a heterodimeric cytokine signals through the il-17ra/IL-17RC receptor complex .J. Immunol., Aug 2008; 181: 2799 - 2805.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
86,240 Da
NCBI Official Full Name
interleukin-17 receptor C isoform 4
UniProt Protein Name
Interleukin-17 receptor C
UniProt Gene Name
IL17RC
UniProt Synonym Gene Names
IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL
UniProt Entry Name
I17RC_HUMAN
Similar Products
Product Notes
The IL17RC il17rc (Catalog #AAA76118) is a Recombinant Protein produced from HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-17RC Fc tagged, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.