Application Data
VEGF-C active protein
Human VEGF-C
Gene Names
VEGFC; VRP; Flt4-L
Reactivity
Human
Purity
> 90% by SDS-PAGE & silver stain
Synonyms
VEGF-C; N/A; Human VEGF-C; Recombinant Human Vascular Endothelial Growth Factor-C; VRP; Flt4-L; VEGF-related protein; VEGF-C active protein
Host
Insect Cells
Reactivity
Human
Purity/Purification
> 90% by SDS-PAGE & silver stain
Form/Format
Lyophilized
Sequence
N-Terminal Sequence: DPTEETI
Sequence Length
121
N Terminal Sequence
DPTEETI
Buffer
Water
Preparation and Storage
Lyophilized samples are stable for more than six months at -20 degree C to -70 degree C. Reconstituted VEGF-C should be stored in working aliquots at -20 degree C. Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for VEGF-C active protein
VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 121 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
Product Categories/Family for VEGF-C active protein
References
1. Joukov et al., EMBO J 15:290, 1996 2. Olofsson et al., Curr Opin Biotech 10:528, 1999 3. Kukk et al., Development 122:3829, 1996
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18-24 kDa
NCBI Official Full Name
vascular endothelial growth factor C preproprotein
NCBI Official Synonym Full Names
vascular endothelial growth factor C
NCBI Official Symbol
VEGFC
NCBI Official Synonym Symbols
VRP; Flt4-L
NCBI Protein Information
vascular endothelial growth factor C; VEGF-C; FLT4 ligand DHM; vascular endothelial growth factor-related protein
UniProt Protein Name
Vascular endothelial growth factor C
UniProt Gene Name
VEGFC
UniProt Synonym Gene Names
VEGF-C; Flt4-L; VRP
UniProt Entry Name
VEGFC_HUMAN
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Product Notes
The VEGF-C vegfc (Catalog #AAA79143) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Human VEGF-C reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: N-Terminal Sequence: DPTEETI. It is sometimes possible for the material contained within the vial of "VEGF-C, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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