Application Data
(The purity of MLL1 (KMT2A) was determined to be >90%by densitometry, approx. MW 52kDa.)
MLL1 recombinant protein
MLL1 (KMT2A), Active
Gene Names
KMT2A; HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS
Purity
> 90%
Synonyms
MLL1; N/A; MLL1 (KMT2A), Active; MLL1 recombinant protein
Purity/Purification
> 90%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1 ug/ul (varies by lot)
Sequence Positions
3738-end
Sequence Length
16599
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Stable for 1 year at -70°C from date of receipt.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Stable for 1 year at -70°C from date of receipt.
Application Data
(The purity of MLL1 (KMT2A) was determined to be >90%by densitometry, approx. MW 52kDa.)
Application Data
(The purity of MLL1 (KMT2A) was determined to be >90%by densitometry, approx. MW 52kDa.)
Application Data
(The specific activity of MLL1 (KMT2A) was determined to be 600pmol/min/mgas per activity assay protocol.)
Application Data
(The specific activity of MLL1 (KMT2A) was determined to be 600pmol/min/mgas per activity assay protocol.)
Related Product Information for MLL1 recombinant protein
Description: Recombinant human MLL1 (3738-end ) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The MLL1 (KMT2A) protein accession number is NM_005933.
Scientific Background: Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.
Scientific Background: Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.
Product Categories/Family for MLL1 recombinant protein
References
1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15 (6): 334-46. 2015. 2. http://www.uniprot.org/uniprot/Q
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
Homo sapiens lysine methyltransferase 2A (KMT2A), transcript variant 2, mRNA
NCBI Official Synonym Full Names
lysine methyltransferase 2A
NCBI Official Symbol
KMT2A
NCBI Official Synonym Symbols
HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS
NCBI Protein Information
histone-lysine N-methyltransferase 2A
UniProt Protein Name
Histone-lysine N-methyltransferase 2A
UniProt Gene Name
KMT2A
UniProt Synonym Gene Names
ALL1; CXXC7; HRX; HTRX; MLL; MLL1; TRX1; Lysine N-methyltransferase 2A; p320; p180
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Product Notes
The MLL1 kmt2a (Catalog #AAA73021) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 3738-end. It is sometimes possible for the material contained within the vial of "MLL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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