Application Data
(Coomassie gel stain of Human dGAE Tau protein monomer (AAA254086). Load: 2 ug. Lane 1: MW ladder. Lane 2: AAA254086.)
Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers Recombinant Protein | dGAE recombinant protein
Human Recombinant Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers
Gene Names
MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
Applications
SDS-Page, Western Blot
Purity
>95%; Ion-exchange Purified
Synonyms
Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers; N/A; Human Recombinant Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers; Tau Truncated Fragment (AA297-391)(dGAE) Monomers; Truncated Tau Fragment (AA297-391)(dGAE); Tau monomer; Tau protein monomer; Tau protein; microtubule-associated protein Tau; MAPT; MAP; microtubule-associated protein; Truncated Tau Protein Monomer; Paired Helical Filament-Tau; Phf-Tau; Neurofibrillary Tangle Protein; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Isoform 2; tubulin-associated unit; 95-amino acid Tau protein fragment; Truncated Tau Protein; dGAE recombinant protein
Host
E coli
Purity/Purification
>95%; Ion-exchange Purified
Form/Format
10mM PB pH 7.4
Concentration
2 mg/ml (varies by lot)
Sequence
IKHVPGGGSV QIVYKPVDLS KVTSKCGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAE
Applicable Applications for dGAE recombinant protein
Invitro Assay, SDS-PAGE, WB (Western Blot)
Species
Human
Tag
No tag
Research Area
Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Cytoskeleton, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Tangles & Tau
Cellular Localization
Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex
Nature
Recombinant
Certificate of Analysis
Certified >95% pure using SDS-PAGE analysis. Low endotoxin <5 EU/mL @ 2mg/mL.
Cellular Localization
Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasm, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -80 degree C. Avoid freeze/thaw cycles
Application Data
(Coomassie gel stain of Human dGAE Tau protein monomer (AAA254086). Load: 2 ug. Lane 1: MW ladder. Lane 2: AAA254086.)
Application Data
(Coomassie gel stain of Human dGAE Tau protein monomer (AAA254086). Load: 2 ug. Lane 1: MW ladder. Lane 2: AAA254086.)
Application Data
(Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE) monomer is combined with truncated tau fragment (AA297-391) (dGAE) Pre-formed fibrils (Type 1).)
Application Data
(Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE) monomer is combined with truncated tau fragment (AA297-391) (dGAE) Pre-formed fibrils (Type 1).)
Product Categories/Family for dGAE recombinant protein
References
1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146-148 (1907)3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429(23):3650-3665 (2017)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10.165 kDa
NCBI Official Full Name
microtubule-associated protein tau isoform 2
NCBI Official Synonym Full Names
microtubule-associated protein tau
NCBI Official Symbol
MAPT
NCBI Official Synonym Symbols
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
NCBI Protein Information
microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1
UniProt Protein Name
Microtubule-associated protein tau
UniProt Gene Name
MAPT
UniProt Synonym Gene Names
MAPTL; MTBT1; TAU; PHF-tau
UniProt Entry Name
TAU_HUMAN
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Product Notes
The dGAE mapt (Catalog #AAA254086) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers can be used in a range of immunoassay formats including, but not limited to, Invitro Assay, SDS-PAGE, WB (Western Blot). Researchers should empirically determine the suitability of the dGAE mapt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: IKHVPGGGSV QIVYKPVDLS KVTSKCGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAE. It is sometimes possible for the material contained within the vial of "Truncated Tau Fragment (AA297-391)(dGAE) Protein Monomers, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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