Rabbit TAU Polyclonal Antibody | anti-TAU antibody

TAU Antibody

Cat. Num. AAA40731

• Gene Names: MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: TAU antibody is affinity chromatography purified via peptide column.
• Synonyms: TAU, Antibody; TAU Antibody; Microtubial-associated protein tau; MAPT; MAPTL; DDPAC; FTDP-17L; MSTD; MTBT1; MTBT2; PPND; PPP1R103; microtubule-associated protein tau; anti-TAU antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.
• Purity/Purification: TAU antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 758

• Applicable Applications for anti-TAU antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU.
• Buffer: TAU antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TAU antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

WB (Western Blot)

(Western blot analysis of TAU in (A) human and (B) rat brain tissue lysate with TAU antibody at 1 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of TAU in mouse brain tissue with TAU antibody at 5 μg/ml.)

WB (Western Blot)

(Western blot analysis of TAU in SK-N-SH cell lysate with TAU antibody at 1 μg/ml.)

Related Product Information for anti-TAU antibody

The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).

NCBI and Uniprot Product Information

• NCBI GI #: 294862261
• NCBI GeneID: 4137
• NCBI Accession #: NP_058519
• NCBI GenBank Nucleotide #: NM_016835.4
• UniProt Accession #: P10636; P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3
• Molecular Weight: Predicted: 83 kDa; ; Observed: 90 kDa
• NCBI Official Full Name: microtubule-associated protein tau isoform 1
• NCBI Official Synonym Full Names: microtubule-associated protein tau
• NCBI Official Symbol: MAPT
• NCBI Official Synonym Symbols: TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• NCBI Protein Information: microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1
• UniProt Protein Name: Microtubule-associated protein tau
• UniProt Gene Name: MAPT
• UniProt Synonym Gene Names: MAPTL; MTBT1; TAU; PHF-tau
• UniProt Entry Name: TAU_HUMAN