WB (Western Blot)
(ACE2 (SARS Receptor) Antibody (Center) western blot analysis in 293,K562,MCF-7,SK-BR-3,T47D,MDA-MB-453 cell line and mouse testis tissue lysates (35ug/lane).This demonstrates the ACE2 antibody detected the ACE2 protein (arrow).)
Mouse anti-Human, Mouse ACE2 Monoclonal Antibody | anti-ACE2 antibody
ACE2 Antibody
Gene Names
ACE2; ACEH
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Synonyms
ACE2, Antibody; ACE2 Antibody; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2; ACE2; anti-ACE2 antibody
Host
Mouse
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgM,k
Clone Number
881CT16.4.4
Specificity
Purified His-tagged ACE2 protein was used to produced this monoclonal antibody.
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Length
805
Applicable Applications for anti-ACE2 antibody
ELISA, WB (Western Blot)
Antigen Type
Recombinant Protein
Function
Essential counter-regulatorycarboxypeptidase of the renin- angiotensinhormone system that is a critical regulatorof blood volume, systemic vascularresistance, and thus cardiovascularhomeostasis (PubMed: ). Convertsangiotensin I to angiotensin 1- 9, anine-amino acid peptide withanti-hypertrophic effects in cardiomyocytes,and angiotensin II to angiotensin 1-7, whichthen acts as a beneficial vasodilator andanti-proliferation agent, counterbalancingthe actions of the vasoconstrictorangiotensin II (PubMed: ,PubMed: ,PubMed: ,PubMed: ,PubMed: ). Alsoremoves the C-terminal residue from threeother vasoactive peptides, neurotensin,kinetensin, and des-Arg bradykinin, but isnot active on bradykinin (PubMed: ,PubMed: ). Alsocleaves other biological peptides, such asapelins (apelin-13, [Pyr1]apelin-13,apelin-17, apelin-36), casomorphins(beta-casomorphin- 7, neocasomorphin)and dynorphin A with high efficiency(PubMed: ,PubMed: ,PubMed: ). Inaddition, ACE2 C-terminus is homologous tocollectrin and is responsible for thetrafficking of the neutral amino acidtransporter SL6A19 to the plasmamembrane of gut epithelial cells via directinteraction, regulating its expression on thecell surface and its catalytic activity(PubMed: ,PubMed: ).
Cellular Location
[Processed angiotensin-converting enzyme2]: Secreted
Tissue Location
Expressed in endothelial cells from smalland large arteries, and in arterial smoothmuscle cells (at protein level)(PubMed:15141377). Expressed inenterocytes of the small intestine, Leydigcells and Sertoli cells (at protein level)(PubMed:15141377) Expressed in the renalproximal tubule and the small intestine (atprotein level) (PubMed:18424768).Expressed in heart, kidney, testis, andgastrointestinal system (at protein level)(PubMed:10969042, PubMed:10924499,PubMed:15231706, PubMed:12459472,PubMed:15671045, PubMed:32715618,PubMed:32170560). In lung, expressed atlow levels in some alveolar type 2 cells, theexpression seems to be individual- specific(at protein level) (PubMed:32425701,PubMed:15141377, PubMed:32715618,PubMed:32170560). Coexpressed withTMPRSS2 within some lung alveolar type 2cells, ileal absorptive enterocytes, intestinalepithelial cells, cornea, gallbladder andnasal goblet secretory cells(PubMed:32413319, PubMed:32327758,PubMed:32358202). Coexpressed withTMPRSS4 within mature enterocytes(PubMed:32404436)
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(ACE2 (SARS Receptor) Antibody (Center) western blot analysis in 293,K562,MCF-7,SK-BR-3,T47D,MDA-MB-453 cell line and mouse testis tissue lysates (35ug/lane).This demonstrates the ACE2 antibody detected the ACE2 protein (arrow).)
WB (Western Blot)
(ACE2 (SARS Receptor) Antibody (Center) western blot analysis in 293,K562,MCF-7,SK-BR-3,T47D,MDA-MB-453 cell line and mouse testis tissue lysates (35ug/lane).This demonstrates the ACE2 antibody detected the ACE2 protein (arrow).)
Related Product Information for anti-ACE2 antibody
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Product Categories/Family for anti-ACE2 antibody
References
Donoghue M., et al. Circ. Res. 87:E1-E9(2000).
Tipnis S.R., et al. J. Biol. Chem. 275:33238-33243(2000).
Douglas G.C., et al. Endocrinology 145:4703-4711(2004).
Itoyama S., et al. Am. J. Med. Genet. A 136:52-57(2005).
Suzuki Y., et al. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Tipnis S.R., et al. J. Biol. Chem. 275:33238-33243(2000).
Douglas G.C., et al. Endocrinology 145:4703-4711(2004).
Itoyama S., et al. Am. J. Med. Genet. A 136:52-57(2005).
Suzuki Y., et al. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
angiotensin-converting enzyme 2
NCBI Official Synonym Full Names
angiotensin I converting enzyme 2
NCBI Official Symbol
ACE2
NCBI Official Synonym Symbols
ACEH
NCBI Protein Information
angiotensin-converting enzyme 2
UniProt Protein Name
Angiotensin-converting enzyme 2
UniProt Gene Name
ACE2
UniProt Synonym Gene Names
ACEH
UniProt Entry Name
ACE2_HUMAN
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Product Notes
The ACE2 ace2 (Catalog #AAA283459) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ACE2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ACE2 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ACE2 ace2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACE2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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