IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human liver stained with Alpha-2-Macroglobulin Mouse Monoclonal Antibody (A2M/3622).)
Mouse anti-Human Alpha-2-Macroglobulin Monoclonal Antibody | anti-A2M antibody
Alpha-2-Macroglobulin Mouse Monoclonal Antibody [Clone A2M/3622]
Gene Names
A2M; A2MD; CPAMD5; FWP007; S863-7
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
Alpha-2-Macroglobulin, Antibody; Alpha-2-Macroglobulin Mouse Monoclonal Antibody [Clone A2M/3622]; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Alpha-2-M (A2M); CPAMD5; anti-A2M antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse/IgG2b, kappa
Clone Number
A2M/3622
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-A2M antibody
IHC (Immunohistochemistry)
Immunogen
Human recombinant A2M protein fragment (around aa 604-748) (exact sequence is proprietary)
Cellular Localization
Secreted in plasma
Positive Control
Human liver or placenta tissues.
Hu-chromosome Location
12p13.31
Unigene
212838
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human liver stained with Alpha-2-Macroglobulin Mouse Monoclonal Antibody (A2M/3622).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human liver stained with Alpha-2-Macroglobulin Mouse Monoclonal Antibody (A2M/3622).)
Related Product Information for anti-A2M antibody
alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serum is primarily bound to alpha-2M, which renders TGFbeta inactive. alpha-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of alpha-2M in mediating the clearance and degradation of A beta, the major component of beta-Amyloid deposits accumulated during AD.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
163,291 Da
NCBI Official Full Name
alpha-2-macroglobulin
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
A2M
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
NCBI Protein Information
alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Gene Name
A2M
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M
UniProt Entry Name
A2MG_HUMAN
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Product Notes
The A2M a2m (Catalog #AAA215694) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Alpha-2-Macroglobulin Mouse Monoclonal Antibody [Clone A2M/3622] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Alpha-2-Macroglobulin can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the A2M a2m for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alpha-2-Macroglobulin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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