IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with ARG1 Monoclonal Antibody (ARG1/1125 + ARG1/1126).)
Mouse Arginase 1 Monoclonal Antibody | anti-ARG1 antibody
Arginase 1 (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody
Reactivity
Human; Others not known
Applications
Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
Synonyms
Arginase 1, Antibody; Arginase 1 (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody; Arginase 1; ARG1; liver-type arginase; type I arginase; anti-ARG1 antibody
Host
Mouse
Reactivity
Human; Others not known
Clonality
Monoclonal
Isotype
IgG3, kappa + Mouse / IgG3, kappa
Clone Number
ARG1/1125 + ARG1/1126
Specificity
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
322
Applicable Applications for anti-ARG1 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
Cellular Localization
Cytoplasmic
Immunogen
Recombinant human ARG1 protein fragment (around aa11-97) (exact sequence is proprietary)
Hu-Chromosome Location
6q23
Positive Control
293T cells. Hepatocellular Carcinoma (HCC).
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with ARG1 Monoclonal Antibody (ARG1/1125 + ARG1/1126).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with ARG1 Monoclonal Antibody (ARG1/1125 + ARG1/1126).)
References
Diez, A., et al. 1994. Immunological identity of the two different molecular mass constitutive subunits of liver arginase. Biol. Chem. Hoppe Seyler 375: 537-541
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35-38kDa
NCBI Official Full Name
arginase-1 isoform 2
NCBI Official Synonym Full Names
arginase 1
NCBI Official Symbol
ARG1
NCBI Protein Information
arginase-1
UniProt Protein Name
Arginase-1
UniProt Gene Name
ARG1
UniProt Entry Name
ARGI1_HUMAN
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Product Notes
The ARG1 arg1 (Catalog #AAA62732) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Arginase 1 (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody reacts with Human; Others not known and may cross-react with other species as described in the data sheet. AAA Biotech's Arginase 1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the ARG1 arg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Arginase 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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