Rat CD11b Monoclonal Antibody | anti-CD11b antibody
Anti-Ms CD11b Purified
Gene Names
Itgam; CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik
Reactivity
Mouse, Rabbit, Human, Non-human primates
Applications
Immunohistochemistry, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Purified by Protein-G Affinity Chromatography
Synonyms
CD11b, Antibody; Anti-Ms CD11b Purified; integrin subunit alpha M; Mac-1; Integrin alpha M; ITGAM; CR3A; MO1A; MAC1A; anti-CD11b antibody
Host
Rat
Reactivity
Mouse, Rabbit, Human, Non-human primates
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
M1/70
Specificity
The rat monoclonal antibody M1/70 detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions.
Purity/Purification
Purified by Protein-G Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Applicable Applications for anti-CD11b antibody
IHC (Immunohistochemistry), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
Immunogen
B10 mouse spleen cells enriched for T cells
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD11b antibody
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
NCBI and Uniprot Product Information
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Product Notes
The CD11b (Catalog #AAA128687) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ms CD11b Purified reacts with Mouse, Rabbit, Human, Non-human primates and may cross-react with other species as described in the data sheet. AAA Biotech's CD11b can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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