Rabbit anti-Human CD137/4-1BB/TNFRSF9 Monoclonal Antibody | anti-TNFRSF9 antibody

CD137/4-1BB/TNFRSF9

Cat. Num. AAA215500

• Gene Names: TNFRSF9; ILA; 4-1BB; CD137; CDw137
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay, ELISA
• Purity: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: CD137/4-1BB/TNFRSF9, Antibody; CD137/4-1BB/TNFRSF9; 4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of mouse 4 1BB; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9; anti-TNFRSF9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 4-1BB/4552R
• Specificity: CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.
• Purity/Purification: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 1.0mg/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
• Sequence Length: 255

• Applicable Applications for anti-TNFRSF9 antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA
• Immunogen: A recombinant fragment (around aa 19-188) of Human CD137 protein (exact sequence is proprietary)
• Cellular Localization: Cell Surface
• Antibody Type: Recombinant Antibody
• Hu-chromosome Location: 1p36.23
• Positive Control: HEK293 cells, Jurkat whole cell lysate or Recombinant human CD137 protein (WB). Human kidney cancer, Liver, Stomach or Thyroid cancer tissue (IHC-P). Expressed on the surface of activated T-cells.
• Preparation and Storage: Antibody without azide: store at -20°C to -80°C.; Non-hazardous. No MSDS required.

WB (Western Blot)

(Western Blot Analysis of kidney tissue lysate using CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).)

References

Zhao S, et al. CD137 ligand is expressed in primary and secondary lymphoid follicles and in B-cell lymphomas: diagnostic and therapeutic implications. Am J Surg Pathol. 2013 Feb;37(2):250-8.

NCBI and Uniprot Product Information

• NCBI GI #: 5730095
• NCBI GeneID: 3604
• NCBI Accession #: NP_001552.2
• NCBI GenBank Nucleotide #: NP_001552.2
• UniProt Accession #: Q07011
• Molecular Weight: 32kDa (monomer); 85kDa (dimer)
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 9
• NCBI Official Synonym Full Names: TNF receptor superfamily member 9
• NCBI Official Symbol: TNFRSF9
• NCBI Official Synonym Symbols: ILA; 4-1BB; CD137; CDw137
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 9
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 9
• UniProt Gene Name: TNFRSF9
• UniProt Synonym Gene Names: CD137; ILA
• UniProt Entry Name: TNR9_HUMAN