Mouse anti-Human CD180 Monoclonal Antibody | anti-CD180 antibody
Anti-Hu CD180 Purified Low Endotoxin
Gene Names
CD180; LY64; Ly78; RP105
Reactivity
Human
Applications
Functional Assay, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD180, Antibody; Anti-Hu CD180 Purified Low Endotoxin; CD180 molecule; LY64; Ly78; RP105; Bgp95; anti-CD180 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
G28-8
Specificity
The mouse monoclonal antibody G28-8 recognizes an extracellular epitope of CD180, a 95-105 kDa TLR-like glycoprotein expressed on peripheral blood monocytes and dendritic cells, mantle zone B cells and marginal zone B cells, but very weakly on germinal center B cells.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
Concentration
1 mg/ml (varies by lot)
Sequence Length
661
Applicable Applications for anti-CD180 antibody
FA (Functional Assay), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
Immunogen
Human tonsillar B cells
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD180 antibody
CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
RP105
NCBI Official Synonym Full Names
CD180 molecule
NCBI Official Symbol
CD180
NCBI Official Synonym Symbols
LY64; Ly78; RP105
NCBI Protein Information
CD180 antigen
UniProt Protein Name
CD180 antigen
UniProt Gene Name
CD180
UniProt Synonym Gene Names
LY64; RP105
UniProt Entry Name
CD180_HUMAN
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Product Notes
The CD180 cd180 (Catalog #AAA128541) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD180 Purified Low Endotoxin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD180 can be used in a range of immunoassay formats including, but not limited to, FA (Functional Assay), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD180 cd180 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD180, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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