Mouse anti-Rat CD3 Monoclonal Antibody | anti-CD3 antibody
Anti-Rat CD3 SAFIRE Purified
Reactivity
Rat
Applications
Functional Assay, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
The monoclonal antibody was purified utilizing affinity chromatography.
Synonyms
CD3, Antibody; Anti-Rat CD3 SAFIRE Purified; anti-CD3 antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
Mouse IgG3, kappa
Clone Number
G4.18
Purity/Purification
The monoclonal antibody was purified utilizing affinity chromatography.
Form/Format
Phosphate-buffered aqueous solution, ph7.2.
Concentration
1mg/mL (varies by lot)
Applicable Applications for anti-CD3 antibody
FA (Functional Assay), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
Endotoxin
The endotoxin level is determined by LAL test to be less than 0.01 EU/ug of the protein.
Conjugation
SAFIRE Purified
Preparation and Storage
Product should be kept at 2-8°C and protected from prolonged exposure to light. The product shold be stored undiluted at 4°C. Do not freeze.
Related Product Information for anti-CD3 antibody
The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.
References
Nicolls, M. R., Aversa, G. G., Pearce, N. W., Spinelli, A., Berger, M. F., Gurley, K. E., & Hall, B. M. (1993). Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.Transplantation, 55(3), 459-468.
Morris, D. L., & Komocsar, W. J. (1997). Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods, 37(1), 37-46.
Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M.,... & Hodgkinson, S. J. (2001). Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4. International immunology, 13(9), 1109-1120.
Morris, D. L., & Komocsar, W. J. (1997). Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods, 37(1), 37-46.
Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M.,... & Hodgkinson, S. J. (2001). Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4. International immunology, 13(9), 1109-1120.
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Product Notes
The CD3 (Catalog #AAA79340) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Rat CD3 SAFIRE Purified reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD3 can be used in a range of immunoassay formats including, but not limited to, FA (Functional Assay), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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