Mouse anti-Human CD369 Monoclonal Antibody | anti-CD369 antibody
Anti-Hu CD369 Purified
Gene Names
CLEC7A; BGR; CANDF4; DECTIN1; CLECSF12
Reactivity
Human
Applications
Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Purified by protein-A affinity chromatography
Synonyms
CD369, Antibody; Anti-Hu CD369 Purified; Dectin-1; CLEC7A; BGR; CANDF4; SCARE2; C-type lectin domain containing 7A; anti-CD369 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2a kappa
Clone Number
1500
Specificity
The mouse monoclonal antibody 15E2 recognizes an extracellular epitope LWEDGSTFSSN of human CD369 (Dectin-1), a 33kDa transmembrane glycoprotein expressed predominantly on dendritic cells.
Purity/Purification
Purified by protein-A affinity chromatography
Form/Format
Purified. Phosphate buffered saline (PBS) solution with 15mM sodium azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD369 antibody
IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
Immunogen
Extracellular part of human CD369 with hIgG FC tag
Preparation and Storage
Store at 2-8 degree C. Do not freeze. Do not use after expiration date stamped on the label.
Related Product Information for anti-CD369 antibody
CD369 (Dectin-1, beta-glucan receptor) is a 33kDa type II transmembrane glycoprotein of lectin family, and serves as a part of innate immunity system by binding to beta-glucan polymers, which are typical for yeast and mycobacterial cell walls. CD369 is expressed predominantly on dendritic cells, but it can be detected also on monocytes, macrophages, mast cells, eosinophils, B cells, endothelial cells, and sometimes also on some T cell subsets.
References
*Ni L, Gayet I, Zurawski S, Duluc D, Flamar AL, Li XH, O'Bar A, Clayton S, Palucka AK, G Zurawski, Banchereau J, Oh SK: Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses. J Immunol. 2010 Sep 15;185(6):3504-13, URL: https://pubmed.ncbi.nlm.nih.gov/20729328/from_term=ni+l+gayet+i+zurawski+s&from_pos=2,*Fischer M, Müller JP, Spies-Weisshart B, Gräfe C, Kurzai O, Hünniger K, Hochhaus A, Scholl S, Schnetzke U. Isoform localization of dectin-1 regulates the signaling quality of anti-fungal immunity. Eur J Immunol. 2017 May;47(5):848-859, URL: https://pubmed.ncbi.nlm.nih.gov/28303575/from_term=scholl+s+hochhaus+a&from_pos=5,*Joo H, Upchurch K, Zhang W, Ni L, Li D, Xue Y, Li XH, Hori T, Zurawski S, Liu YJ, Zurawski G, Oh S: Opposing roles of dectin-1 expressed on human plasmacytoid dendritic cells and myeloid dendritic cells in Th2 polarization. J Immunol. 2015 Aug 15;195(4):1723-31, URL: https://pubmed.ncbi.nlm.nih.gov/26123355/from_term=zhang+w+xue+y&from_page=6&from_pos=10
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,627 Da
NCBI Official Full Name
C-type lectin domain family 7 member A isoform b
NCBI Official Synonym Full Names
C-type lectin domain family 7, member A
NCBI Official Symbol
CLEC7A
NCBI Official Synonym Symbols
BGR; CANDF4; DECTIN1; CLECSF12
NCBI Protein Information
C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-typ
UniProt Protein Name
C-type lectin domain family 7 member A
UniProt Gene Name
CLEC7A
UniProt Synonym Gene Names
BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1
UniProt Entry Name
CLC7A_HUMAN
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Product Notes
The CD369 clec7a (Catalog #AAA129109) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD369 Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD369 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD369 clec7a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD369, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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