Mouse CD49d Monoclonal Antibody | anti-CD49d antibody
Anti-Hu CD49d Purified
Gene Names
ITGA4; IA4; CD49D
Reactivity
Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human
Applications
Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD49d, Antibody; Anti-Hu CD49d Purified; integrin subunit alpha 4; ITGA4; Integrin alpha-4; VLA-4 alpha; VLA4 alpha; anti-CD49d antibody
Host
Mouse
Reactivity
Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
9F10
Specificity
The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
1032
Applicable Applications for anti-CD49d antibody
IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD49d antibody
CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer's patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Integrin alpha-4
NCBI Official Synonym Full Names
integrin subunit alpha 4
NCBI Official Symbol
ITGA4
NCBI Official Synonym Symbols
IA4; CD49D
NCBI Protein Information
integrin alpha-4
UniProt Protein Name
Integrin alpha-4
UniProt Gene Name
ITGA4
UniProt Synonym Gene Names
CD49D
UniProt Entry Name
ITA4_HUMAN
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Product Notes
The CD49d itga4 (Catalog #AAA128393) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD49d Purified reacts with Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD49d can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD49d itga4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD49d, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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