IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).)
Mouse CDX2 Monoclonal Antibody | anti-CDX2 antibody
CDX2 (GI Epithelial Marker)
Gene Names
CDX2; CDX3; CDX-3; CDX2/AS
Reactivity
Human. Others not known.
Applications
Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay, ELISA
Synonyms
CDX2, Antibody; CDX2 (GI Epithelial Marker); Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX2; anti-CDX2 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
CDX2/1690
Specificity
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
313
Applicable Applications for anti-CDX2 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA
Immunogen
Recombinant human CDX2 protein fragment (aa150-249)
Cellular Localization
Nuclear
Hu-chromosome Location
13q12.2
Positive Control
HT29 cells or Colon Carcinoma
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).)
References
Silberg, D.G., et al. 2000. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119: 961-971. Mallo, G.V., et al. 1998. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J. Biol. Chem. 273: 14030-14036.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40kDa
NCBI Official Full Name
homeobox protein CDX-2 isoform 1
NCBI Official Synonym Full Names
caudal type homeobox 2
NCBI Official Symbol
CDX2
NCBI Official Synonym Symbols
CDX3; CDX-3; CDX2/AS
NCBI Protein Information
homeobox protein CDX-2
UniProt Protein Name
Homeobox protein CDX-2
UniProt Gene Name
CDX2
UniProt Synonym Gene Names
CDX3
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Product Notes
The CDX2 cdx2 (Catalog #AAA62911) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CDX2 (GI Epithelial Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's CDX2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA. Researchers should empirically determine the suitability of the CDX2 cdx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDX2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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