Mouse anti-Mouse CRAMP Monoclonal Antibody | anti-CRAMP antibody
CRAMP, Mouse, mAb LF7-BB3
Reactivity
Mouse
Applications
Functional Assay
Synonyms
CRAMP, Antibody; CRAMP, Mouse, mAb LF7-BB3; Cathelicidin antimicrobial peptide; Cathelin-like protein; CLP - Gene name: Camp; Cnlp; Cramp Entrez Gene ID: 12796 Uniprot: P51437; anti-CRAMP antibody
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
LF7-BB3
Form/Format
0.2 ml (100 ug/ml) 0.2 um filtered in PBS+0.1%BSA
Applicable Applications for anti-CRAMP antibody
IA (Immunoassay), FA (Functional Assay)
Immunogen
Full length mouse CRAMP peptide.
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
Related Product Information for anti-CRAMP antibody
The monoclonal antibody LF7-BB3 recognizes the mouse protein Cathelin-Related AntiMicrobial Peptide (Cramp). Cathelicidins are a familiy of antimicrobial proteins predominantly found in the peroxidase-negative granules of neutrophils. the cathelicidins are synthesized as preproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The biologic active domains of the cathelicidins reside in the C-terminus. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophilic granules. Cramp (Cathelin-Related Anti-Microbial Peptide) is the mouse analogue of human LL-37 peptide, which is the antibacterial C-terminus of hCAP-18 (human cathelicidin). CRAMP forms an amphipathic alpha-helix similar to other antimicrobial peptides. Cramp is a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. Abundant expression of Cramp is found in myeloid precursors and neutrophils. Cramp represents the first antibiotic peptide found in cells of myeloid lineage in the mouse. Inflammatory cells in the mouse can thus use a non-oxidative mechanism for microbial killing. The monoclonal antibody LF7-BB3 is suitable as a capture and/or detection in an immunoassay (ELISA).
Product Categories/Family for anti-CRAMP antibody
Similar Products
Product Notes
The CRAMP (Catalog #AAA77815) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CRAMP, Mouse, mAb LF7-BB3 reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CRAMP can be used in a range of immunoassay formats including, but not limited to, IA (Immunoassay), FA (Functional Assay). Researchers should empirically determine the suitability of the CRAMP for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRAMP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.