Mouse anti-Human CXCL11 Monoclonal Antibody | anti-CXCL11 antibody

Anti-CXCL11 Antibody, Mouse Monoclonal

Cat. Num. AAA255233

• Gene Names: CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Immunohistochemistry
• Purity: Protein A
• Synonyms: CXCL11, Antibody; Anti-CXCL11 Antibody, Mouse Monoclonal; I-TAC/CXCL11 Antibody, Mouse MAb; chemokine (C-X-C motif) ligand 11; Anti-b-R1 Antibody; Anti-H174 Antibody; Anti-I-TAC Antibody; Anti-IP-9 Antibody; Anti-IP9 Antibody; Anti-SCYB11 Antibody; Anti-SCYB9B Antibody; anti-CXCL11 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 08
• Specificity: Human I-TAC/CXCL11
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CXCL11 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry)
• Immunogen: Recombinant Human I-TAC/CXCL11 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human I-TAC/CXCL11 (rh I-TAC/CXCL11). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining of human CXCL11 in human kidney with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).)

IHC (Immunohistochemistry)

(Immunochemical staining of human CXCL11 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-CXCL11 antibody

I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

References

Strausberg RL, et al. (2003) Generation and initial analysis of more than 15, 000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903. Rani MR, et al. (2002) Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. J Biol Chem. 277(41): 38456-61. Salmaggi A, et al. (2003) Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J Interferon Cytokine Res. 22(6):631-40.

NCBI and Uniprot Product Information

• NCBI GI #: 7674360
• NCBI GeneID: 6373
• UniProt Accession #: O14625; Q53YA3; Q92840
• Molecular Weight: 94
• NCBI Official Full Name: C-X-C motif chemokine 11
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 11
• NCBI Official Symbol: CXCL11
• NCBI Official Synonym Symbols: IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• NCBI Protein Information: C-X-C motif chemokine 11; beta-R1; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small indu
• UniProt Protein Name: C-X-C motif chemokine 11
• UniProt Gene Name: CXCL11
• UniProt Synonym Gene Names: ITAC; SCYB11; SCYB9B; IP-9; I-TAC
• UniProt Entry Name: CXL11_HUMAN