IHC (Immunohiostchemistry)
Rabbit Cyclin D1 Monoclonal Antibody | anti-CCND1 antibody
Cyclin D1 RMab
Gene Names
CCND1; BCL1; PRAD1; U21B31; D11S287E
Reactivity
Human, Mouse, Rat
Synonyms
Cyclin D1, Antibody; Cyclin D1 RMab; anti-CCND1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT14
Form/Format
Cyclin D1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Breast Carcinomas, Mantle Cell Lymphoma
Localization
Nuclear
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
IHC (Immunohiostchemistry)
IHC (Immunohiostchemistry)
Dilution Info
Dilution Info
Related Product Information for anti-CCND1 antibody
Cyclins are a family of proteins involved in the progression of cells through the cell cycle. Cyclins form a complex with their partner, cyclin-dependent kinase (Cdk), which activates the latter's protein kinase function. Cyclins are so named because they are produced or degraded as needed in order to drive the cell through the different stages of the cell cycle. When its concentrations in the cell are low, the cyclin detaches from the Cdk, inhibiting the enzyme's activity, probably by causing a protein chain to block the enzymatic site. Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell-cycle regulators, and functions in association with Cdk4 and/or Cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including Mantle Cell Lymphomas (MCL).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33598 Da
NCBI Official Full Name
G1/S-specific cyclin-D1
NCBI Official Synonym Full Names
cyclin D1
NCBI Official Symbol
CCND1
NCBI Official Synonym Symbols
BCL1; PRAD1; U21B31; D11S287E
NCBI Protein Information
G1/S-specific cyclin-D1; BCL-1 oncogene; PRAD1 oncogene; OTTHUMP00000237144; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; B-cell lymphoma 1 protein
UniProt Protein Name
G1/S-specific cyclin-D1
UniProt Gene Name
CCND1
UniProt Synonym Gene Names
BCL1; PRAD1
UniProt Entry Name
CCND1_HUMAN
Similar Products
Product Notes
The CCND1 ccnd1 (Catalog #AAA59205) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cyclin D1 RMab reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Cyclin D1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.