Hamster DELTA-LIKE PROTEIN 4 Monoclonal Antibody | anti-Dll4 antibody

HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4

Cat. Num. AAA49798

• Gene Names: Dll4; Delta4
• Applications: Immunohistochemistry, Functional Assay, Flow Cytometry, Functional Assay, Immunohistochemistry
• Synonyms: DELTA-LIKE PROTEIN 4, Antibody; HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4; anti-Dll4 antibody

• Host: Hamster
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: HMD4-2
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0mg/ml (varies by lot)
• Sequence Length: 686

• Applicable Applications for anti-Dll4 antibody: IHC (Immunohistochemistry), FA (Functional Assay), FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry)
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3) ; Preparation
• Immunogen: Recombinant mouse DLL4.; Histology Positive Control Tissue
• Target Species: Mouse
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Application Data

(Mouse Delta like protein 4 transfected cells stained with Hamster anti Mouse Delta Like Protein 4:RPE (AAA49798PE))

Application Data

(Mouse Delta like protein 4 transfected cells stained with Hamster anti Mouse Delta Like Protein 4)

Related Product Information for anti-Dll4 antibody

Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 specifically recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL4 is expressed by vascular endothelium, and plays a vital role in embryonic vascular development. DLL4 signalling has been shown to play a role in the angiogenesis of clear-cell renal tumours, and pancreatic, bladder and colonic cancer. Studies have shown that DLL4 expression in endothelium cells, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, and by HIF1 alpha, and that blockade of DLL4 inhibits tumour growth by promoting non-productive angiogenesis. Hamster anti Mouse Delta-Like Protein 4 ant

NCBI and Uniprot Product Information

• NCBI GI #: 244799228
• NCBI GeneID: 54485
• NCBI Accession #: NP_062327.2
• NCBI GenBank Nucleotide #: NM_019454.3
• UniProt Accession #: Q9JI71; Q9DBU9; Q9JHZ7
• Molecular Weight: 74,991 Da
• NCBI Official Full Name: delta-like protein 4
• NCBI Official Synonym Full Names: delta-like 4 (Drosophila)
• NCBI Official Symbol: Dll4
• NCBI Official Synonym Symbols: Delta4
• NCBI Protein Information: delta-like protein 4; drosophila Delta homolog 4
• UniProt Protein Name: Delta-like protein 4
• UniProt Gene Name: Dll4
• UniProt Synonym Gene Names: Delta4
• UniProt Entry Name: DLL4_MOUSE