FCM/FACS (Flow Cytometry)
(Intracellular FLOW analysis of Jurkat cells using 0.5 ug of antibody. Red represents FITC conjugated DR4 antibody AAA78399 (Clone: ABM1B11). Green represents FITC conjugated mouse IgG1 isotope control.)
Mouse anti-Human DR4 Monoclonal Antibody | anti-DR4 antibody
Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated
Gene Names
TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
PurifiedProtein G Chromatography
Synonyms
DR4, Antibody; Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated; TNFRSF10A; APO2; DR4; TRAILR1; Death receptor 4; TRAIL receptor 1; TNF-related apoptosis-inducing ligand receptor 1; anti-DR4 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
ABM1B11
Purity/Purification
Purified
Protein G Chromatography
Protein G Chromatography
Form/Format
100ug in 500ul Tris and 0.05% sodium azide. Sodium azide is highly toxic
Sequence Length
468
Applicable Applications for anti-DR4 antibody
FCM/FACS (Flow Cytometry)
Immunogen
A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody.
Conjugation
FITC
Preparation and Storage
Store the antibody at 4 degree C; stable for 6 months.
FCM/FACS (Flow Cytometry)
(Intracellular FLOW analysis of Jurkat cells using 0.5 ug of antibody. Red represents FITC conjugated DR4 antibody AAA78399 (Clone: ABM1B11). Green represents FITC conjugated mouse IgG1 isotope control.)
FCM/FACS (Flow Cytometry)
(Intracellular FLOW analysis of Jurkat cells using 0.5 ug of antibody. Red represents FITC conjugated DR4 antibody AAA78399 (Clone: ABM1B11). Green represents FITC conjugated mouse IgG1 isotope control.)
Related Product Information for anti-DR4 antibody
Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.
Product Categories/Family for anti-DR4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10A
NCBI Official Synonym Full Names
TNF receptor superfamily member 10a
NCBI Official Symbol
TNFRSF10A
NCBI Official Synonym Symbols
DR4; APO2; CD261; TRAILR1; TRAILR-1
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10A
UniProt Gene Name
TNFRSF10A
UniProt Synonym Gene Names
APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1
Similar Products
Product Notes
The DR4 tnfrsf10a (Catalog #AAA78399) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DR4 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the DR4 tnfrsf10a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DR4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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