IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with E-Cadherin Mouse Monoclonal Antibody (CDH1/4585).)
Mouse E-Cadherin(CDH1)/CD324 Monoclonal Antibody | anti-CDH1 antibody
E-Cadherin(CDH1)/CD324 (Intercellular Junction Marker) Mouse Monoclonal Antibody [Clone CDH1/4585]
Gene Names
CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; CD324
Reactivity
Human and Mouse.
Applications
Immunohistochemistry
Synonyms
E-Cadherin(CDH1)/CD324, Antibody; E-Cadherin(CDH1)/CD324 (Intercellular Junction Marker) Mouse Monoclonal Antibody [Clone CDH1/4585]; E-Cadherin(CDH1)/CD324 (Intercellular Junction Marker); Arc 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD324; CDH1; CDHE; E-Cad/CTF3; ECAD; Epithelial cadherin; epithelial calcium dependent adhesion protein; Liver cell adhesion molecule (LCAM); Uvomorulin (UVO); anti-CDH1 antibody
Host
Mouse
Reactivity
Human and Mouse.
Clonality
Monoclonal
Isotype
Mouse/IgG1, kappa
Clone Number
CDH1/4585
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-CDH1 antibody
IHC (Immunohistochemistry)
Immunogen
Purified His-tagged CDH1 protein
Cellular Localization
Cell Surface
Positive Control
MCF-7 or SK-BR3 cells. Human prostate or colon carcinomas.
Hu-chromosome Location
16q22.1
Unigene
461086
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with E-Cadherin Mouse Monoclonal Antibody (CDH1/4585).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with E-Cadherin Mouse Monoclonal Antibody (CDH1/4585).)
Related Product Information for anti-CDH1 antibody
E-cadherin is a transmembrane, calcium dependent cell adhesion protein that mediates cell to cell adhesion and maintains structural and functional integrity of epithelial tissues. It also has pivotal barrier functions and maintains the polarity of epithelial cells. Reduced or aberrant E-cadherin expression breaks cell to cell contacts, and thus, cells acquire the ability to migrate. In normal tissues, immunostaining of E-cadherin is localized to the membrane of epithelial cells, consistent with its role in cell adhesion. And in tumor tissues, E-cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, gastrointestinal tract, and ovary. It has also been shown to be positive in some thyroid carcinomas. A combination of E-cadherin and p120 catenin may help distinguish ductal carcinoma of the breast from lobular carcinoma. And also, several studies have reported that reduced E-cadherin expression is correlated with poor prognosis in several types of carcinomas.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
97,456 Da
NCBI Official Full Name
cadherin-1 preproprotein
NCBI Official Synonym Full Names
cadherin 1, type 1, E-cadherin (epithelial)
NCBI Official Symbol
CDH1
NCBI Official Synonym Symbols
UVO; CDHE; ECAD; LCAM; Arc-1; CD324
NCBI Protein Information
cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial
UniProt Protein Name
Cadherin-1
UniProt Gene Name
CDH1
UniProt Synonym Gene Names
CDHE; UVO; E-cadherin
UniProt Entry Name
CADH1_HUMAN
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Product Notes
The CDH1 cdh1 (Catalog #AAA216082) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The E-Cadherin(CDH1)/CD324 (Intercellular Junction Marker) Mouse Monoclonal Antibody [Clone CDH1/4585] reacts with Human and Mouse. and may cross-react with other species as described in the data sheet. AAA Biotech's E-Cadherin(CDH1)/CD324 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CDH1 cdh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E-Cadherin(CDH1)/CD324, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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