Mouse anti-Human Elastin (ELN) Monoclonal Antibody | anti-ELN antibody

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis)

Cat. Num. AAA215403

• Gene Names: ELN; WS; WBS; SVAS; ADCL1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Elastin (ELN), Antibody; Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis); Elastin; ELN; SVAS; Tropoelastin; WBS; WS; anti-ELN antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: ELN/2069
• Specificity: Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 786

• Applicable Applications for anti-ELN antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant full-length Human Elastin protein
• Cellular Localization: Secreted and Extracellular Space
• Hu-chromosome Location: 7q11.23
• Positive Control: A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS_PAGE

(SDS-PAGE Analysis Purified Elastin Mouse Monoclonal Antibody (ELN/2069). Confirmation of Integrity and Purity of Antibody.)

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human Angiosarcoma stained with Elastin Mouse Monoclonal Antibody (ELN/2069).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Small Intestine stained with Elastin Mouse Monoclonal Antibody (ELN/2069).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Pancreas stained with Elastin Mouse Monoclonal Antibody (ELN/2069).)

References

Fazio, M.J., et al. 1991. Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am. J. Hum. Genet. 48: 696-703.

NCBI and Uniprot Product Information

• NCBI GI #: 525313599
• NCBI GeneID: 2006
• NCBI Accession #: NP_001265868.1
• NCBI GenBank Nucleotide #: NP_001265868.1
• UniProt Accession #: P15502
• Molecular Weight: 70kDa
• NCBI Official Full Name: elastin isoform m
• NCBI Official Synonym Full Names: elastin
• NCBI Official Symbol: ELN
• NCBI Official Synonym Symbols: WS; WBS; SVAS; ADCL1
• NCBI Protein Information: elastin
• UniProt Protein Name: Elastin
• UniProt Gene Name: ELN
• UniProt Entry Name: ELN_HUMAN