IHC (Immunohiostchemistry)
(Factor H Antibody Immunohistochemistry on an FFPE SARS-Cov-2 Infected Lung Tissue)
Mouse anti-Human Factor H/Complement Factor H Monoclonal Antibody
Factor H/Complement Factor H (BSB-164)
Reactivity
Human
Synonyms
Factor H/Complement Factor H, Antibody; Factor H/Complement Factor H (BSB-164); factor h; factor-h; anti-factor h; anti-factor-h; complement factor h; anti complement factor h; cfh; anti-cfh; anti-Factor H/Complement Factor H antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-164
Form/Format
Paraffin, Frozen
Factor H is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Factor H is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human complement factor H protein.
Control
Testis, Liver, Kidney, Pancreas, Adrenal Gland
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(Factor H Antibody Immunohistochemistry on an FFPE SARS-Cov-2 Infected Lung Tissue)
IHC (Immunohiostchemistry)
(Factor H Antibody Immunohistochemistry on an FFPE SARS-Cov-2 Infected Lung Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-Factor H/Complement Factor H antibody
Factor H or Complement Factor H (CFH), is the major soluble inhibitor of complement, where its binding to self markers (i.e. particular glycan structures) prevents complement activation and amplification on host surfaces. Mutations and polymorphisms that affect recognition of self markers by Factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical hemolytic uremic syndrome. In addition, pathogens and cancer cells can hijack Factor H to evade the immune response.
Lung, Ovarian, Glial and Colon Cancer cells show enhanced expression and surface binding of soluble regulators, including Factor H. Factor H antibody has been shown to be expressed by human Breast Cancer cells, which correlates with the presence of immunosuppressive macrophages, Breast Cancer recurrence and severity of the disease. Lung cancer cells may develop a protective mechanism against complement attack by expressing and binding Factor H to their cell membranes. Additionally, it has been demonstrated that Factor H is upregulated by constitutive activation of STAT4, which is accounted for by SOCS silencing in Lung Cancer cells. Several studies have also suggested the importance of Factor H in the protection of tumor cells against complement activation. The importance of Factor H antibody expression for the protection of cancer cells in vivo will help to elucidate the mechanisms used by tumor cells to avoid complement activity and assist in the design of more efficient complement-mediated immunotherapies.
Lung, Ovarian, Glial and Colon Cancer cells show enhanced expression and surface binding of soluble regulators, including Factor H. Factor H antibody has been shown to be expressed by human Breast Cancer cells, which correlates with the presence of immunosuppressive macrophages, Breast Cancer recurrence and severity of the disease. Lung cancer cells may develop a protective mechanism against complement attack by expressing and binding Factor H to their cell membranes. Additionally, it has been demonstrated that Factor H is upregulated by constitutive activation of STAT4, which is accounted for by SOCS silencing in Lung Cancer cells. Several studies have also suggested the importance of Factor H in the protection of tumor cells against complement activation. The importance of Factor H antibody expression for the protection of cancer cells in vivo will help to elucidate the mechanisms used by tumor cells to avoid complement activity and assist in the design of more efficient complement-mediated immunotherapies.
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Product Notes
The Factor H/Complement Factor H (Catalog #AAA59367) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Factor H/Complement Factor H (BSB-164) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Factor H/Complement Factor H, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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