Mouse anti-Human Fatty Acid Binding Protein/FABP1 Monoclonal Antibody | anti-FABP1 antibody

Fatty Acid Binding Protein (Liver)/FABP1

Cat. Num. AAA215457

• Gene Names: FABP1; FABPL; L-FABP
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Fatty Acid Binding Protein/FABP1, Antibody; Fatty Acid Binding Protein (Liver)/FABP1; FABP1; L-FABP; anti-FABP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone Number: FABP1/3483
• Specificity: Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP). FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 127

• Applicable Applications for anti-FABP1 antibody: IHC (Immunohistochemistry)
• Immunogen: Human recombinant FABP1 protein fragment (around aa1-127) (exact sequence is proprietary)
• Cellular Localization: Cytoplasmand Nuclear
• Hu-chromosome Location: 2p11.2
• Positive Control: Liver or Colon carcinoma tissues (IHC). Kidney tissue lysates (WB).
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Application Data

(Analysis of Protein Array containing more than 19,000 full-length human proteins using FABP1 Mouse Monoclonal Antibody (FABP1/3483). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)

SDS-PAGE

(SDS-PAGE Analysis Purified FABP1 Mouse Monoclonal Antibody (FABP1/3483). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human liver carcinoma stained with FABP1 Mouse Monoclonal Antibody (FABP1/3483).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human kidney stained with FABP1 Mouse Monoclonal Antibody (FABP1/3483).)

References

Kaikaus, R.M., et al. 1993. Mechanisms of regulation of liver fatty acid binding protein. Mol. Cell. Biochem. 123: 93-100.

NCBI and Uniprot Product Information

• NCBI GI #: 182358
• NCBI GeneID: 2168
• UniProt Accession #: P07148
• Molecular Weight: 14kDa
• NCBI Official Full Name: L-FABP
• NCBI Official Synonym Full Names: fatty acid binding protein 1
• NCBI Official Symbol: FABP1
• NCBI Official Synonym Symbols: FABPL; L-FABP
• NCBI Protein Information: fatty acid-binding protein, liver
• UniProt Protein Name: Fatty acid-binding protein, liver
• UniProt Gene Name: FABP1
• UniProt Synonym Gene Names: FABPL; L-FABP
• UniProt Entry Name: FABPL_HUMAN