WB (Western Blot)
(Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies))
Mouse anti-Human FGFR4 Monoclonal Antibody | anti-FGFR4 antibody
FGFR4 Antibody
Gene Names
FGFR4; TKF; JTK2; CD334
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified Mouse Monoclonal Antibody (Mab)
Synonyms
FGFR4, Antibody; FGFR4 Antibody; Fibroblast growth factor receptor 4; FGFR-4; CD334; FGFR4; JTK2; TKF; anti-FGFR4 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 κ
Clone Number
53CT32.19.3
Specificity
Purified recombinant FGFR4 fusion protein was used to produced this monoclonal antibody.
Purity/Purification
Purified Mouse Monoclonal Antibody (Mab)
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Vial Concentration: 0.35 (varies by lot)
Sequence Length
802
Applicable Applications for anti-FGFR4 antibody
ELISA, WB (Western Blot)
Antigen Type
Recombinant Protein
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies))
WB (Western Blot)
(Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies))
WB (Western Blot)
(Western blot analysis of anti-FGFR4 Monoclonal Antibody by FGFR4 recombinant protein(Fragment 42KD). FGFR4 protein (arrow) was detected using the purified Mab.)
WB (Western Blot)
(Western blot analysis of anti-FGFR4 Monoclonal Antibody by FGFR4 recombinant protein(Fragment 42KD). FGFR4 protein (arrow) was detected using the purified Mab.)
Related Product Information for anti-FGFR4 antibody
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Product Categories/Family for anti-FGFR4 antibody
References
Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis. Rao AS, et al. Gastroenterology, 2010 Aug 4. PMID 20691689.
Influence of the Fibroblast Growth Factor Receptor 4 Expression and the G388R Functional Polymorphism on Cushing's Disease Outcome. Brito LP, et al. J Clin Endocrinol Metab, 2010 Jul 21. PMID 20660043.
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Ho-Pun-Cheung A, et al. Pharmacogenomics J, 2010 Jul 20. PMID 20644561.
FGFR4 transmembrane domain polymorphism and cancer risk: A meta-analysis including 8555 subjects. Xu W, et al. Eur J Cancer, 2010 Jul 16. PMID 20638838.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Influence of the Fibroblast Growth Factor Receptor 4 Expression and the G388R Functional Polymorphism on Cushing's Disease Outcome. Brito LP, et al. J Clin Endocrinol Metab, 2010 Jul 21. PMID 20660043.
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Ho-Pun-Cheung A, et al. Pharmacogenomics J, 2010 Jul 20. PMID 20644561.
FGFR4 transmembrane domain polymorphism and cancer risk: A meta-analysis including 8555 subjects. Xu W, et al. Eur J Cancer, 2010 Jul 16. PMID 20638838.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
87954
NCBI Official Full Name
fibroblast growth factor receptor 4 isoform 1
NCBI Official Synonym Full Names
fibroblast growth factor receptor 4
NCBI Official Symbol
FGFR4
NCBI Official Synonym Symbols
TKF; JTK2; CD334
NCBI Protein Information
fibroblast growth factor receptor 4
UniProt Protein Name
Fibroblast growth factor receptor 4
UniProt Gene Name
FGFR4
UniProt Synonym Gene Names
JTK2; TKF; FGFR-4
UniProt Entry Name
FGFR4_HUMAN
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Product Notes
The FGFR4 fgfr4 (Catalog #AAA283486) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FGFR4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FGFR4 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the FGFR4 fgfr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FGFR4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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