Mouse Galectin-1/Placental Lactogen (hPL) Monoclonal Antibody | anti-hPL antibody

Galectin-1/Human Placental Lactogen (hPL)

Cat. Num. AAA214431

• Gene Names: LGALS1; GBP; GAL1
• Reactivity: Human. Others not known.
• Applications: Immunohistochemistry, Western Blot, Immunofluorescence, Flow Cytometry, Functional Assay, ELISA
• Synonyms: Galectin-1/Placental Lactogen (hPL), Antibody; Galectin-1/Human Placental Lactogen (hPL); 14kDa laminin-binding protein; Beta-galactoside-binding lectin L-14-I; Gal-1; GAL1; Galaptin; Galectin-1; HLBP14; HPL; Lactose-binding lectin 1; Lect14; Lectin galactoside-binding soluble 1; LGALS1; MAPK activating protein MP12; S-Lac lectin 1; anti-hPL antibody

• Host: Mouse
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG1, lambda
• Clone Number: GAL1/1831
• Specificity: Galectin-1 is a member of the beta-galactoside-binding family and is a dimeric protein of 14kD participating in a variety of normal and pathological processes, including cancer progression. Galectin-1 can affect the proliferation of normal and malignant cells. Inhibition of cell growth is observed in a lactose-dependent manner as lower concentrations of the lectin stimulate cell proliferation. Galectin-1 may also be implicated in the induction of apoptosis of activated T cells through the binding of exogenous galectin-1 to CD45 molecules present on the surface of lymphocytes. Galectin-1, reported to be present either at the surface of cancer cells or accumulated around these cells could act as an immunological shield to protect against a T cell immune response and provide an advantage for survival.
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 135

• Applicable Applications for anti-hPL antibody: IHC (Immunohistochemistry), WB (Western Blot), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA
• Immunogen: Recombinant human Galectin-1 protein fragment (aa12-108)
• Cellular Localization: Secreted (extracellular matrix)
• Hu-chromosome Location: 22q13.1
• Positive Control: HeLa, K562 or 293 cells. Prostate, Kidney, Placenta, Stomach, Skin, Spleen, Brain or Heart.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

WB (Western Blot)

(Western Blot of HeLa, A431, K562 and 293 Cell Lysates using Galectin-1 Monoclonal Antibody (GAL1/1831).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded Human Prostate Carcinoma stained with Galectin-1 Monoclonal Antibody (GAL1/1831).)

References

Couraud, P.O., et al. 1989. Molecular cloning, characterization, and expression of a human 14 kDa lectin. J. Biol. Chem. 264: 1310-1316.

NCBI and Uniprot Product Information

• NCBI GI #: 4504981
• NCBI GeneID: 3956
• NCBI Accession #: NP_002296.1
• NCBI GenBank Nucleotide #: NM_002305.3
• UniProt Accession #: P09382; Q9UDK5; B2R5E8
• Molecular Weight: 14kDa
• NCBI Official Full Name: galectin-1
• NCBI Official Synonym Full Names: galectin 1
• NCBI Official Symbol: LGALS1
• NCBI Official Synonym Symbols: GBP; GAL1
• NCBI Protein Information: galectin-1
• UniProt Protein Name: Galectin-1
• UniProt Gene Name: LGALS1
• UniProt Synonym Gene Names: Gal-1; HLBP14