Mouse anti-Human Gastrin Monoclonal Antibody | anti-GAST antibody

Gastrin

Cat. Num. AAA214981

• Gene Names: GAST; GAS
• Reactivity: Human
• Applications: ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Gastrin, Antibody; Gastrin; Component II; GAS; Gast; Gastrin component I; Gastrin component II; Gastrin component III; Gastrin precursor; Gastrin-14; Gastrin-17; Gastrin-34; Gastrin-52; Gastrin-6; Gastrin-71; anti-GAST antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: GAST/2634
• Specificity: Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 101

• Applicable Applications for anti-GAST antibody: ELISA
• Positive Control: Human Pituitary or Stomach.
• Immunogen: Recombinant full-length human GAST protein
• Cellular Localization: Secreted.
• Hu-chromosome Location: 17q21.2.
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified Gastrin Mouse Monoclonal Antibody (GAST/2634). Confirmation of Integrity and Purity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Stomach stained with Gastrin Mouse Monoclonal Antibody (GAST/2634).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Stomach stained with Gastrin Mouse Monoclonal Antibody (GAST/2634).)

References

Gregory, R.A., et al. 1969. Gut 10: 603

NCBI and Uniprot Product Information

• NCBI GI #: 4503923
• NCBI GeneID: 2520
• NCBI Accession #: NP_000796.1
• NCBI GenBank Nucleotide #: NP_000796.1
• UniProt Accession #: P01350
• Molecular Weight: 2/4/14kDa
• NCBI Official Full Name: gastrin preproprotein
• NCBI Official Synonym Full Names: gastrin
• NCBI Official Symbol: GAST
• NCBI Official Synonym Symbols: GAS
• NCBI Protein Information: gastrin
• UniProt Protein Name: Gastrin
• UniProt Gene Name: GAST
• UniProt Synonym Gene Names: GAS; G52; G34; G17; G14; G6
• UniProt Entry Name: GAST_HUMAN