Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GPN1 Mouse Monoclonal Antibody (GPN1/2350) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse GPN1/XAB1 Monoclonal Antibody | anti-GPN1 antibody
GPN1/XAB1 (DNA Repair & Protein Synthesis)
Gene Names
GPN1; XAB1; MBDIN; NTPBP; RPAP4; ATPBD1A
Reactivity
Human. Others not known.
Applications
Immunohistochemistry, ELISA
Synonyms
GPN1/XAB1, Antibody; GPN1/XAB1 (DNA Repair & Protein Synthesis); ATP(GTP) binding protein (ATPBD1A); GPN-loop GTPase 1; GPN1; MBD2-interacting protein (MBDin); NTPBP; RNA polymerase II associated protein 4 (RPAP4); XPA-binding protein 1 (XAB1) GTPase; anti-GPN1 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
GPN1/2350
Specificity
GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
362
Applicable Applications for anti-GPN1 antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant full-length human GPN1 protein
Cellular Localization
Cytoplasmic & Nuclear
Hu-chromosome Location
2p23.3
Positive Control
Pancreas, Testis, Thyroid or Bladder.
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GPN1 Mouse Monoclonal Antibody (GPN1/2350) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GPN1 Mouse Monoclonal Antibody (GPN1/2350) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS-PAGE
(SDS-PAGE Analysis Purified GPN1 Mouse Monoclonal Antibody (GPN1/2350).Confirmation of Purity and Integrity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified GPN1 Mouse Monoclonal Antibody (GPN1/2350).Confirmation of Purity and Integrity of Antibody.)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with GPN1 Mouse Monoclonal Antibody (GPN1/2350).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Pancreas stained with GPN1 Mouse Monoclonal Antibody (GPN1/2350).)
References
Nitta, M., et al. 2000. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res. 28: 4212-4218.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42kDa
NCBI Official Full Name
GPN-loop GTPase 1 isoform b
NCBI Official Synonym Full Names
GPN-loop GTPase 1
NCBI Official Symbol
GPN1
NCBI Official Synonym Symbols
XAB1; MBDIN; NTPBP; RPAP4; ATPBD1A
NCBI Protein Information
GPN-loop GTPase 1
UniProt Protein Name
GPN-loop GTPase 1
UniProt Gene Name
GPN1
UniProt Synonym Gene Names
MBDin
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Product Notes
The GPN1 gpn1 (Catalog #AAA214641) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GPN1/XAB1 (DNA Repair & Protein Synthesis) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's GPN1/XAB1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the GPN1 gpn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPN1/XAB1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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