Application Data
(Immobilized human GUCY2C His at 2 ug/mL can bind Anti-GUCY2C Reference Antibody (indusatumab), EC50=0.00818ug/mL)
GUCY2C recombinant antibody
Anti-GUCY2C Reference Antibody (indusatumab)
Gene Names
GUCY2C; STAR; DIAR6; GUC2C; MECIL; MUCIL
Reactivity
Human, Rat, Pig, Cynomolgus
Applications
Flow Cytometry, Functional Assay
Synonyms
GUCY2C, Recombinant Antibody; Anti-GUCY2C Reference Antibody (indusatumab); GUCY2C recombinant antibody
Host
CHO Cell
Reactivity
Human, Rat, Pig, Cynomolgus
Clonality
Monoclonal
Isotype
IgG1
Specificity
GUCY2C
Form/Format
Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Applicable Applications for GUCY2C recombinant antibody
FCM/FACS (Flow Cytometry)
Endotoxin
< 0.001EU/ug, determined by LAL method.
Conjugation
Unconjugated
Function
Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:, PubMed: , PubMed: , PubMed: , PubMed: ). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed: , PubMed: ). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed: ).
Cellular Location
Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -20 degree C in small aliquots to prevent freeze/thaw cycles
Application Data
(Immobilized human GUCY2C His at 2 ug/mL can bind Anti-GUCY2C Reference Antibody (indusatumab), EC50=0.00818ug/mL)
Application Data
(Immobilized human GUCY2C His at 2 ug/mL can bind Anti-GUCY2C Reference Antibody (indusatumab), EC50=0.00818ug/mL)
Application Data
(The purity of Anti-GUCY2C Reference Antibody (indusatumab)is more than 98.5% ,determined by SEC-HPLC.)
Application Data
(The purity of Anti-GUCY2C Reference Antibody (indusatumab)is more than 98.5% ,determined by SEC-HPLC.)
SDS-PAGE
(Anti-GUCY2C Reference Antibody (indusatumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%)
SDS-PAGE
(Anti-GUCY2C Reference Antibody (indusatumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%)
Product Categories/Family for GUCY2C recombinant antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
145.18 kDa
NCBI Official Full Name
heat-stable enterotoxin receptor
NCBI Official Synonym Full Names
guanylate cyclase 2C
NCBI Official Symbol
GUCY2C
NCBI Official Synonym Symbols
STAR; DIAR6; GUC2C; MECIL; MUCIL
NCBI Protein Information
heat-stable enterotoxin receptor
UniProt Protein Name
Heat-stable enterotoxin receptor
UniProt Gene Name
GUCY2C
UniProt Synonym Gene Names
GUC2C; STAR; STA receptor; hSTAR; GC-C
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Product Notes
The GUCY2C gucy2c (Catalog #AAA296827) is a Recombinant Antibody produced from CHO Cell and is intended for research purposes only. The product is available for immediate purchase. The Anti-GUCY2C Reference Antibody (indusatumab) reacts with Human, Rat, Pig, Cynomolgus and may cross-react with other species as described in the data sheet. AAA Biotech's GUCY2C can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the GUCY2C gucy2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GUCY2C, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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