SDS-PAGE
(SDS-PAGE Analysis of Purified hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54).)
Mouse HCG-beta Monoclonal Antibody | anti-HCG-beta antibody
HCG-beta (Pregnancy & Choriocarcinoma Marker)
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
HCG-beta, Antibody; HCG-beta (Pregnancy & Choriocarcinoma Marker); CG-beta; CGB3; CGB5; CGB7; CGB8; Choriogonadotropin Subunit beta; hCGB; anti-HCG-beta antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
rHCGb/54
Specificity
This MAb reacts with a protein of 22kDa, identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the and subunits. The subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applicable Applications for anti-HCG-beta antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant full-length hCG beta protein
Cellular Localization
Cytoplasmic, secreted
Hu-chromosome Location
19q13.33
Positive Control
JAR or TT Cells. Placenta
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
SDS-PAGE
(SDS-PAGE Analysis of Purified hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54).)
SDS-PAGE
(SDS-PAGE Analysis of Purified hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human placenta stained with hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human placenta stained with hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54).)
References
1.Cocquebert M et. al. Am J Physiol Endocrinol Metab. 2012; 303(8):E950-8.
NCBI and Uniprot Product Information
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Product Notes
The HCG-beta (Catalog #AAA62922) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HCG-beta (Pregnancy & Choriocarcinoma Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's HCG-beta can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the HCG-beta for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCG-beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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