Mouse HPV-18 (Human Papilloma Virus 18) Monoclonal Antibody | anti-HPV-18 antibody

HPV-18 (Human Papilloma Virus 18)

Cat. Num. AAA215323

• Reactivity: Type 18 of Human Papilloma Virus (HPV-18)
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: HPV-18 (Human Papilloma Virus 18), Antibody; HPV-18 (Human Papilloma Virus 18); E6; Human Papilloma Virus; HPV type 18 E6; Protein E6; anti-HPV-18 antibody

• Host: Mouse
• Reactivity: Type 18 of Human Papilloma Virus (HPV-18)
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: HPV18/1297
• Specificity: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

• Applicable Applications for anti-HPV-18 antibody: IHC (Immunohistochemistry)
• Positive Control: HPV-18 infected cells. Cervical tissue.
• Immunogen: HPV18 E6-β-galactosidase fusion protein
• Cellular Localization: Nuclear
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV18/1297).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV18/1297).)

References

Reich, N.C., et al. 1983. Mol. Cell. Biol. 3: 2143-2150.