SDS-PAGE
(SDS-PAGE Analysis Purified HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4). Confirmation of Purity and Integrity of Antibody.)
Mouse HPV16 E1/E4 (Human Papilloma Virus 16) Monoclonal Antibody
HPV16 E1/E4 (Human Papilloma Virus 16)
Reactivity
Type 16 of Human Papilloma Virus (HPV-16)
Applications
Immunohistochemistry
Purity
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Synonyms
HPV16 E1/E4 (Human Papilloma Virus 16), Antibody; HPV16 E1/E4 (Human Papilloma Virus 16); HPV-16; HPV-16 capsid; HPV16 L1; HPV16 major capsid protein L1; Human papillomavirus type 16 L1; Human papillomavirus type 16 major capsid protein L1; anti-HPV16 E1/E4 (Human Papilloma Virus 16) antibody
Host
Mouse
Reactivity
Type 16 of Human Papilloma Virus (HPV-16)
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
HPV16 E1/E4
Specificity
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applicable Applications for anti-HPV16 E1/E4 (Human Papilloma Virus 16) antibody
IHC (Immunohistochemistry)
Positive Control
HPV-16 infected cells. Cervical tissue.
Immunogen
Recombinant human HPV16 E1/E4 fragment (aa 36-41).
Cellular Localization
Nuclear
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
SDS-PAGE
(SDS-PAGE Analysis Purified HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4). Confirmation of Purity and Integrity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4). Confirmation of Purity and Integrity of Antibody.)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).)
References
Reich, N.C., et al. 1983. Mol. Cell. Biol. 3: 2143-2150.
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Product Notes
The HPV16 E1/E4 (Human Papilloma Virus 16) (Catalog #AAA215348) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HPV16 E1/E4 (Human Papilloma Virus 16) reacts with Type 16 of Human Papilloma Virus (HPV-16) and may cross-react with other species as described in the data sheet. AAA Biotech's HPV16 E1/E4 (Human Papilloma Virus 16) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the HPV16 E1/E4 (Human Papilloma Virus 16) for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HPV16 E1/E4 (Human Papilloma Virus 16), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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