Mouse Human Immunodeficiency Virus Type-1 p24 Monoclonal Antibody | anti-gag-pol antibody
Human Immunodeficiency Virus Type-1 p24
Reactivity
HIV Type 1. Others not known.
Applications
Immunofluorescence, Immunocytochemistry, ELISA
Synonyms
Human Immunodeficiency Virus Type-1 p24, Antibody; Human Immunodeficiency Virus Type-1 p24; Capsid protein p24; Human immunodeficiency virus type 1 p24; HIV1gp1; HIV-1 Gag p24; anti-gag-pol antibody
Host
Mouse
Reactivity
HIV Type 1. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
HIV1-24/661
Specificity
Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Sequence Length
1435
Applicable Applications for anti-gag-pol antibody
IF (Immunofluorescence), ICC (Immunocytochemistry), ELISA
Localization
Membrane
Positive Control
HIV-1 infected cells or tissues.
Immunogen
Recombinant HIV-1 Gag p24 protein
Preparation and Storage
Store at 2 to 8 degree C. Antibody is stable for 24 months.
References
1. Voltersvik, P., Bostad, L., Dyrhol-Riise, A.M., Eide, G.E., Rosok, B.I., Olofsson, J. and Asjö, B. 2006. Cystatin A and HIV-1 p24 antigen expression in tonsil- lar lymphoid follicles during HIV-1 infection and during highly active anti- retroviral therapy. J. Acquir. Immune Defic. Syndr. 41: 277-2784.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24kDa (mature); 55kDa; 41kDa (precursors)
NCBI Official Full Name
Gag-Pol
NCBI Official Symbol
gag-pol
NCBI Protein Information
Gag-Pol; Gag-Pol polyprotein; Gag-Pol Transframe peptide; aspartic peptidase; p66 subunit; integrase; reverse transcriptase p51 subunit
UniProt Protein Name
Gag-Pol polyprotein
UniProt Gene Name
P04585.
UniProt Synonym Gene Names
MA; CA; NC; TF; p6*; IN
UniProt Entry Name
POL_HV1H2
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Product Notes
The gag-pol p04585. (Catalog #AAA62580) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Human Immunodeficiency Virus Type-1 p24 reacts with HIV Type 1. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's Human Immunodeficiency Virus Type-1 p24 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), ICC (Immunocytochemistry), ELISA. Researchers should empirically determine the suitability of the gag-pol p04585. for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Human Immunodeficiency Virus Type-1 p24, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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