IL-1RAP/IL-1R3 recombinant antibody

Anti-IL-1RAP/IL-1R3 Reference Antibody (Nadunolimab)

Cat. Num. AAA297099

• Gene Names: IL1RAP; IL1R3; C3orf13; IL-1RAcP
• Reactivity: Human, Mouse
• Applications: ELISA, Flow Cytometry, Functional Assay
• Synonyms: IL-1RAP/IL-1R3, Recombinant Antibody; Anti-IL-1RAP/IL-1R3 Reference Antibody (Nadunolimab); IL-1RAP/IL-1R3 recombinant antibody

• Host: CHO Cell
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: IL-1RAP/IL-1R3
• Form/Format: Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for IL-1RAP/IL-1R3 recombinant antibody: ELISA, FCM/FACS (Flow Cytometry)
• Endotoxin: < 0.001EU/ug, determined by LAL method.
• Conjugation: Unconjugated
• Expression system: CHO cell.
• Function: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells ( Probable).
• Cellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted.
• Tissue location: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -20C. Avoid repeated freeze-thaw cycles.

Application Data

(The purity of Anti-IL-1RAP / IL-1R3 Reference Antibody (Nadunolimab)is more than 100% ,determined by SEC-HPLC.)

SDS-PAGE

(Anti-IL-1RAP / IL-1R3 Reference Antibody (Nadunolimab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%)

Product Categories/Family for IL-1RAP/IL-1R3 recombinant antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 268840341
• NCBI GeneID: 3556
• NCBI Accession #: NP_001161402.1
• NCBI GenBank Nucleotide #: NM_001167930.1
• UniProt Accession #: Q9NPH3; O14915; Q86WJ7; B1NLD0; D3DNW0
• Molecular Weight: Calculated MW: 144.28 kDa
• NCBI Official Full Name: interleukin-1 receptor accessory protein isoform 2
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein
• NCBI Official Symbol: IL1RAP
• NCBI Official Synonym Symbols: IL1R3; C3orf13; IL-1RAcP
• NCBI Protein Information: interleukin-1 receptor accessory protein; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta
• UniProt Protein Name: Interleukin-1 receptor accessory protein
• UniProt Gene Name: IL1RAP
• UniProt Synonym Gene Names: C3orf13; IL1R3; IL-1 receptor accessory protein; IL-1RAcP; IL-1R-3; IL-1R3
• UniProt Entry Name: IL1AP_HUMAN