Mouse Insulin Monoclonal Antibody | anti-INS antibody

Anti-Insulin Antibody, Mouse Monoclonal

Cat. Num. AAA255303

• Gene Names: INS; ILPR; IRDN; IDDM2; MODY10
• Reactivity: Human, Cynomolgus, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Protein A affinity chromatography
• Synonyms: Insulin, Antibody; Anti-Insulin Antibody, Mouse Monoclonal; Insulin/INS Antibody, Mouse MAb; insulin; Anti-IDDM Antibody; Anti-IDDM1 Antibody; Anti-IDDM2 Antibody; Anti-ILPR Antibody; Anti-INS Antibody; Anti-IRDN Antibody; Anti-MODY10 Antibody; anti-INS antibody

• Host: Mouse
• Reactivity: Human, Cynomolgus, Mouse, Rat
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 14
• Purity/Purification: Protein A affinity chromatography
• Form/Format: 0.2um filtered solution in PBS
• Concentration: 1 mg/mL (varies by lot)

• Applicable Applications for anti-INS antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant Human Insulin/INS Protein
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin/INS (rh Insulin/INS). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 to 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -80 degree C. Preservative-Free.; Sodium azide is recommended to avoid contamination ( final concentration 0.05%-0.1%) it is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

IHC (Immunohistochemistry)

(Immunochemical staining Insulin in mouse pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemisry)

(Immunochemical staining Insulin in rat pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohiostchemistry)

(Immunochemical staining Insulin in cynomolgus pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining Insulin in human pancreas with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-INS antibody

INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.

Product Categories/Family for anti-INS antibody

AMPK Signaling Pathway

References

Veedfald S, Plamboeck A, Deacon C F, et al. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016, 310(1): G43-G51.

NCBI and Uniprot Product Information

• NCBI GI #: 386828
• NCBI GeneID: 3630
• UniProt Accession #: P01308; Q5EEX2
• NCBI Official Full Name: insulin
• NCBI Official Synonym Full Names: insulin
• NCBI Official Symbol: INS
• NCBI Official Synonym Symbols: ILPR; IRDN; IDDM2; MODY10
• NCBI Protein Information: insulin; proinsulin; preproinsulin
• UniProt Protein Name: Insulin
• UniProt Gene Name: INS
• UniProt Entry Name: INS_HUMAN