Rat anti-Human Integrin alpha V + beta 6 Monoclonal Antibody | anti-ITGAV antibody

Integrin alpha V + beta 6 Rat Monoclonal Antibody [Clone AvB6 53a.2]

Cat. Num. AAA216098

• Gene Names: ITGAV; CD51; MSK8; VNRA; VTNR
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: Integrin alpha V + beta 6, Antibody; Integrin alpha V + beta 6 Rat Monoclonal Antibody [Clone AvB6 53a.2]; antigen identified by monoclonal antibody L230; CD 51; CD51; Integrin alpha five; integrin alpha V beta 3; Integrin alpha-V light chain; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGAV; MSK 8; Msk8; Vitronectin receptor subunit alpha; VNRA; VTNR; ITGB6, Integrin, beta 6; anti-ITGAV antibody

• Host: Rat
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rat/IgG2a, kappa
• Clone Number: AvB6 53a.2
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

• Applicable Applications for anti-ITGAV antibody: WB (Western Blot), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6; Cells expressed a mouse/human avb6 chimera.
• Cellular Localization: Cell junction, Cell membrane, Focal adhesion
• Positive Control: Squamous cell carcinoma cells. A375M melanoma cell line. A549 cell line.
• Research Areas: Immunology, Lung Cancer, Signal Transduction
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified CD51/Integrin ?V Rat Monoclonal Antibody (AvB6 53a. 2). Confirmation of Purity and Integrity of Antibody.)

Related Product Information for anti-ITGAV antibody

Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16 alpha and 8 beta subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 223468595
• NCBI GeneID: 3685
• NCBI Accession #: NP_001138471.1
• NCBI GenBank Nucleotide #: NM_001144999.2
• UniProt Accession #: P06756; P18564
• Molecular Weight: 150-160kDa under non-reducing conditions. Under reducing conditions|cleaved into 2 bands of ~125-130kDa +20-25kDa
• NCBI Official Full Name: integrin alpha-V isoform 2
• NCBI Official Synonym Full Names: integrin, alpha V
• NCBI Official Symbol: ITGAV
• NCBI Official Synonym Symbols: CD51; MSK8; VNRA; VTNR
• NCBI Protein Information: integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
• UniProt Protein Name: Integrin alpha-V
• UniProt Gene Name: ITGAV
• UniProt Synonym Gene Names: MSK8; VNRA
• UniProt Entry Name: ITAV_HUMAN