Rabbit anti-Human Interleukin 10 (IL10) Monoclonal Antibody | anti-IL10 antibody

Interleukin 10 (IL10) (Immunoregulation Marker)

Cat. Num. AAA214767

• Gene Names: IL10; CSIF; TGIF; GVHDS; IL-10; IL10A
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: Interleukin 10 (IL10), Antibody; Interleukin 10 (IL10) (Immunoregulation Marker); Cytokine Synthesis Inhibitory Factor (CSIF); GVHDS; IL-10; IL10; IL10A; Interleukin-10; T-cell Growth Inhibitory Factor (TGIF); anti-IL10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: IL10/2651R
• Specificity: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
• Form/Format: 200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05%, BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 178

• Applicable Applications for anti-IL10 antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant full-length human Interleukin 10 (IL10) protein
• Cellular Localization: Cytoplasmic (secreted) and Cell Surface
• Chromosome Location: 1q32.1
• Positive Control: Human adrenal or lymph node tissue (IHC).
• Preparation and Storage: Antibody without azide, store at -20 to -80°C.; Antibody is stable for 12 months.; Non-hazardous.; No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified IL-10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Endo-cervical Carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).)

Related Product Information for anti-IL10 antibody

Recombinant Rabbit Monoclonal Antibody

References

Fleming, S.D. and Campbell, P.A. 1996. Macrophages have cell surface IL-10 that regulates macrophage bactericidal activity. J. Immunol. 156: 1143-1150.; Bromberg, J.S. 1995. IL-10 immunosuppression in transplantation. Curr. Opin. Immunol. 7: 639-643.

NCBI and Uniprot Product Information

• NCBI GI #: 10835141
• NCBI GeneID: 3586
• NCBI Accession #: NP_000563.1
• NCBI GenBank Nucleotide #: NM_000572.3
• UniProt Accession #: P22301
• Molecular Weight: 20kDa (Monomer); 37kDa (Dimer)
• NCBI Official Full Name: interleukin-10
• NCBI Official Synonym Full Names: interleukin 10
• NCBI Official Symbol: IL10
• NCBI Official Synonym Symbols: CSIF; TGIF; GVHDS; IL-10; IL10A
• NCBI Protein Information: interleukin-10
• UniProt Protein Name: Interleukin-10
• UniProt Gene Name: IL10
• UniProt Synonym Gene Names: IL-10; CSIF