Mouse anti-Human IP6K2 Monoclonal Antibody | anti-IP6K2 antibody

Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody

Cat. Num. AAA47750

• Reactivity: Human
• Applications: Immunoblot, Western Blot
• Synonyms: IP6K2, Antibody; Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody; anti-IP6K2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 4F10
• Specificity: IP6K2; This antibody recognizes human IP6K2.
• Form/Format: 100ug in PBS, pH 7.4, purified by Protein G affinity chromatography

• Applicable Applications for anti-IP6K2 antibody: IB (Immunoblot)
• Antigen: Full-length recombinant human IP6K2
• Preservative: None
• Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

Application Data

Related Product Information for anti-IP6K2 antibody

Inositol hexakisphosphate kinase 2 (IP6K2) catalyzes the production of diphosphoinositol pentakisphosphate (IP7) and has a role as a proapoptotic gene sensitizing cancer cells to apoptosis by cell stressors and anticancer drugs all of which depend on IP6K2 catalytic activity. IP6K2 is located in the 3p21.31 chromosomal region, which often undergoes allele loss in a variety of human cancers. Some heat shock proteins, especially Hsp90, can be antiapoptotic and the targets of anticancer drugs. Hsp90 binds IP6K2 and inhibits its catalytic activity. Drugs and selective mutations that abolish HSP90-IP6K2 binding elicit activation of IP6K2, leading to cell death. Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy.

References

• Morrison, BH et al. 2002 Oncogene 21:1882-1889.