Mouse Lipopolysaccharide Core Monoclonal Antibody
Lipopolysaccharide Core, mAb WN1 222-5
Reactivity
Lipopolysaccharide
Applications
Western Blot, Immunohistochemistry, Functional Assay
Synonyms
Lipopolysaccharide Core, Antibody; Lipopolysaccharide Core, mAb WN1 222-5; LPS core; anti-Lipopolysaccharide Core antibody
Host
Mouse
Reactivity
Lipopolysaccharide
Clonality
Monoclonal
Isotype
Mouse IgG2a
Clone Number
222-5
Form/Format
Quantities >500 ug will be send without preservative and carrier free. Quantities <500 ug will be send with preservative and carrier. exact formulation can be found on the datasheet.
Applicable Applications for anti-Lipopolysaccharide Core antibody
WB (Western Blot), IHC (Immunohistochemistry), IA (Immunoassay), FA (Functional Assay)
Immunogen
10E8 heat-killed bacteria
Positive Control
LPS E coli
Negative Control
Normal lymph node (non-infected)
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label
Related Product Information for anti-Lipopolysaccharide Core antibody
Meet the remarkable mouse monoclonal antibody clone WN1 222-5, a precision tool in the realm of immunology. This antibody has a unique ability - it targets the core region of lipopolysaccharide (LPS) with extraordinary accuracy while showing no reactivity to free lipid A, Rd2, or smaller LPS variants. Let's delve into the intriguing world of LPS and its significance.
Lipopolysaccharide (LPS) is a key element of Gram-negative bacteria, infamous for causing infections via strains like E. coli and Salmonella. Comprising three parts—lipid A, core oligosaccharide, and O-polysaccharide—LPS forms the endotoxin essential to bacterial survival and virulence. Understanding the structure of LPS, especially the toxic lipid A and the variable O-polysaccharide, is critical for developing targeted antibacterial treatments.
Humans and vertebrates encounter LPS through exposure to enterobacteria, which release small amounts of endotoxins as they grow. LPS is heat-stable and can cause watery diarrhea and inflammation upon interacting with the digestive tract.
Additionally, LPS also plays a role in conditions like necrotizing enterocolitis (NEC), primarily affecting newborns. If LPS enters the bloodstream, it binds to host cells, triggering complex responses and, in severe cases, organ failure (septic shock).
Furthermore, LPS inhibits Interleukin-6 (IL-6), which presents a strategic method for fine-tuning the body's immune response. As a central cytokine, IL-6 is instrumental in both inflammation control and muscle function, serving a dual role in defense mechanisms and metabolism. Targeting IL-6 inhibition offers a pathway to mitigate conditions characterized by chronic inflammation, such as autoimmune disorders, metabolic syndromes, and certain types of cancers.
Lipopolysaccharide (LPS) is a key element of Gram-negative bacteria, infamous for causing infections via strains like E. coli and Salmonella. Comprising three parts—lipid A, core oligosaccharide, and O-polysaccharide—LPS forms the endotoxin essential to bacterial survival and virulence. Understanding the structure of LPS, especially the toxic lipid A and the variable O-polysaccharide, is critical for developing targeted antibacterial treatments.
Humans and vertebrates encounter LPS through exposure to enterobacteria, which release small amounts of endotoxins as they grow. LPS is heat-stable and can cause watery diarrhea and inflammation upon interacting with the digestive tract.
Additionally, LPS also plays a role in conditions like necrotizing enterocolitis (NEC), primarily affecting newborns. If LPS enters the bloodstream, it binds to host cells, triggering complex responses and, in severe cases, organ failure (septic shock).
Furthermore, LPS inhibits Interleukin-6 (IL-6), which presents a strategic method for fine-tuning the body's immune response. As a central cytokine, IL-6 is instrumental in both inflammation control and muscle function, serving a dual role in defense mechanisms and metabolism. Targeting IL-6 inhibition offers a pathway to mitigate conditions characterized by chronic inflammation, such as autoimmune disorders, metabolic syndromes, and certain types of cancers.
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Product Notes
The Lipopolysaccharide Core (Catalog #AAA77825) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Lipopolysaccharide Core, mAb WN1 222-5 reacts with Lipopolysaccharide and may cross-react with other species as described in the data sheet. AAA Biotech's Lipopolysaccharide Core can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IA (Immunoassay), FA (Functional Assay). Researchers should empirically determine the suitability of the Lipopolysaccharide Core for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lipopolysaccharide Core, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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