IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Monoclonal Antibody (MZ2E/838).)
Mouse anti-Human MAGE-1 Monoclonal Antibody | anti-MAGEA1 antibody
MAGE-1 (Target for Cancer Immunotherapy) Mouse Monoclonal Antibody
Gene Names
MAGEA1; CT1.1; MAGE1
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
Synonyms
MAGE-1, Antibody; MAGE-1 (Target for Cancer Immunotherapy) Mouse Monoclonal Antibody; MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, MAGEA1, Melanoma antigen family A 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E; anti-MAGEA1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
MZ2E/838
Specificity
Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Form/Format
Purified Ab WITHOUT BSA and AZIDE at 1.0 mg/mL.`
Sequence Length
309
Applicable Applications for anti-MAGEA1 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
Cellular Localization
Cytoplasm, Nucleus
Immunogen
Recombinant human MAGEA1 protein
Positive Control
Breast, colorectal, gastric, gliomas. Melanoma cell lines, Melanomas, Neuroblastoma, non-small cell lung, cancer, ovarias and renal cell carcinomas.
Preparation and Storage
Store at 2 to 8 degree C.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Monoclonal Antibody (MZ2E/838).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Monoclonal Antibody (MZ2E/838).)
References
Kobayashi, Y., et al. 2000. Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carci- noma. J. Hepatol. 32: 612-617
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42-46kDa
NCBI Official Full Name
melanoma-associated antigen 1
NCBI Official Synonym Full Names
MAGE family member A1
NCBI Official Symbol
MAGEA1
NCBI Official Synonym Symbols
CT1.1; MAGE1
NCBI Protein Information
melanoma-associated antigen 1
UniProt Protein Name
Melanoma-associated antigen 1
UniProt Gene Name
MAGEA1
UniProt Synonym Gene Names
MAGE1; MAGE1A; CT1.1
UniProt Entry Name
MAGA1_HUMAN
Similar Products
Product Notes
The MAGEA1 magea1 (Catalog #AAA62744) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MAGE-1 (Target for Cancer Immunotherapy) Mouse Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MAGE-1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the MAGEA1 magea1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAGE-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.