Rabbit Major Vault Protein (MVP) Monoclonal Antibody | anti-MVP antibody

Major Vault Protein (MVP)

Cat. Num. AAA214860

• Gene Names: MVP; LRP; VAULT1
• Reactivity: Human. Others not tested.
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Major Vault Protein (MVP), Antibody; Major Vault Protein (MVP); Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1; anti-MVP antibody

• Host: Rabbit
• Reactivity: Human. Others not tested.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: VP2897R
• Specificity: Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 893

• Applicable Applications for anti-MVP antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant full-length human MVP protein
• Positive Control: MCF-7 or HeLa Cells. Breast tumors
• Cellular Localization: Cytoplasmic
• Chromosome Location: 16p11.2
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Major Vault Protein Rabbit Recombinant Monoclonal Antibody (VP2897R).)

SDS-PAGE

(SDS-PAGE Analysis Major Vault Protein Rabbit Recombinant Monoclonal Antibody (VP2897R). Confirmation of Purity and Integrity of Antibody.)

Related Product Information for anti-MVP antibody

Recombinant Rabbit Monoclonal Antibody

References

Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA: Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 1998; 141(6):1301-1310.; Den Boer, M.L. et al. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 91, 2092-2098 (1998).

NCBI and Uniprot Product Information

• NCBI GI #: 645912958
• NCBI GeneID: 9961
• NCBI Accession #: NP_001280133.1
• NCBI GenBank Nucleotide #: NM_001293204.1
• UniProt Accession #: Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1
• Molecular Weight: 104-110kDa
• NCBI Official Full Name: major vault protein isoform 2
• NCBI Official Synonym Full Names: major vault protein
• NCBI Official Symbol: MVP
• NCBI Official Synonym Symbols: LRP; VAULT1
• NCBI Protein Information: major vault protein
• UniProt Protein Name: Major vault protein
• UniProt Gene Name: MVP
• UniProt Synonym Gene Names: LRP; MVP