MICA recombinant antibody

Anti-MICA Reference Antibody (CLN-619)

Cat. Num. AAA297273

• Gene Names: MICA; MIC-A; PERB11.1
• Reactivity: Human, Mouse
• Applications: Flow Cytometry, Functional Assay
• Purity: This antibody is purified through a protein A column.
• Synonyms: MICA, Recombinant Antibody; Anti-MICA Reference Antibody (CLN-619); MICA recombinant antibody

• Host: CHO Cell
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: MICA
• Purity/Purification: This antibody is purified through a protein A column.
• Form/Format: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.

• Applicable Applications for MICA recombinant antibody: FCM/FACS (Flow Cytometry)
• Endotoxin: < 0.001EU/ug, determined by LAL method.
• Conjugation: Unconjugated
• Function: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed: , PubMed: ). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed: ).
• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cytoplasm Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
• Tissue Location: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -80 degree C for 2 years under sterile conditions; -20 degree C for 1 year under sterile conditions; Avoid repeated freeze-thaw cycles.

Application Data

(The purity of Anti-MICA Reference Antibody (CLN-619)is more than 95% ,determined by SEC-HPLC.)

SDS-PAGE

(Anti-MICA Reference Antibody (CLN-619) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%)

Product Categories/Family for MICA recombinant antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 74740024
• NCBI GeneID: 100507436
• UniProt Accession #: Q29983; O60917; O60918; O60919; O60920; O60933; O77956; O78150; A8KQR0; A9LRW5; A9QVE0; B1VJF1
• Molecular Weight: 146.06 kDa
• NCBI Official Full Name: MHC class I polypeptide-related sequence A
• NCBI Official Synonym Full Names: MHC class I polypeptide-related sequence A
• NCBI Official Symbol: MICA
• NCBI Official Synonym Symbols: MIC-A; PERB11.1
• NCBI Protein Information: MHC class I polypeptide-related sequence A; MICA; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A
• UniProt Protein Name: MHC class I polypeptide-related sequence A
• UniProt Gene Name: MICA
• UniProt Synonym Gene Names: MIC-A
• UniProt Entry Name: MICA_HUMAN