CHO Cells anti-Human Mosunetuzumab Monoclonal Antibody | anti-CD3e+CD20 antibody

Mosunetuzumab Biosimilar - Research Grade

Cat. Num. AAA197056

• Gene Names: MS4A1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
• Reactivity: Human
• Applications: Functional Assay
• Purity: >95% by SDS-PAGE under reducing conditions; >95% by SEC-HPLC test.; This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
• Synonyms: Mosunetuzumab, Antibody; Mosunetuzumab Biosimilar - Research Grade; BTCT4465A; anti-CD3e+CD20 antibody

• Host: CHO Cells
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Human IgG1-Kappa
• Specificity: Detects human CD3/CD20.
• Purity/Purification: >95% by SDS-PAGE under reducing conditions; >95% by SEC-HPLC test.; This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
• Form/Format: 1X PBS, pH7.4, sterile filtered, no preservatives
• Concentration: 10.71 mg/mL (varies by lot)

• Applicable Applications for anti-CD3e+CD20 antibody: FA (Functional Assay)
• Target: CD3e/CD20
• Extinction Coefficient: 1.608
• Isotype Note: Bispecific
• Endotoxin: <0.1 EU/mg as determined by the LAL method
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Mosunetuzumab biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

SEC-HPLC

(The purity of AAA197056 is more than 95% verified by SEC-HPLC.)

SDS-PAGE

(AAA197056 on SDS-PAGE under reducing (R)/non-reducing(N-R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.)

Related Product Information for anti-CD3e+CD20 antibody

Mosunetuzumab biosimilar is a bispecific, humanized monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 bispecific monoclonal antibody BTCT4465A contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, BTCT4465A binds to both T cells and CD20-expressing tumor B cells; this cross-links T cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B cells.

Product Categories/Family for anti-CD3e+CD20 antibody

Low endotoxin; biosimilar antibody; Bispecific

NCBI and Uniprot Product Information

• NCBI GI #: 115968
• NCBI GeneID: 931
• UniProt Accession #: P11836; P08984; Q13963; A6NMS4; B4DT24
• Molecular Weight: The predicted MW is 49/50/24/23 kDa
• NCBI Official Full Name: B-lymphocyte antigen CD20
• NCBI Official Synonym Full Names: membrane-spanning 4-domains, subfamily A, member 1
• NCBI Official Symbol: MS4A1
• NCBI Official Synonym Symbols: B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
• NCBI Protein Information: B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
• UniProt Protein Name: B-lymphocyte antigen CD20
• UniProt Gene Name: MS4A1
• UniProt Synonym Gene Names: CD20
• UniProt Entry Name: CD20_HUMAN