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Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using MUC4 Mouse Monoclonal Antibody (MUC4/3105) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse anti-Human MUC4 (Mucin 4/Gastric Mucin) Monoclonal Antibody | anti-MUC4 antibody
MUC4 (Mucin 4/Gastric Mucin)
Gene Names
MUC4; ASGP; MUC-4; HSA276359
Reactivity
Human
Applications
Immunohistochemistry
Purity
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Synonyms
MUC4 (Mucin 4/Gastric Mucin), Antibody; MUC4 (Mucin 4/Gastric Mucin); Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; ASGP; ASGP-1; ASGP-2; Mucin 4 cell surface associated; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; anti-MUC4 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b, kappa
Clone Number
MUC4/3105
Specificity
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100%) and sensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
5412
Applicable Applications for anti-MUC4 antibody
IHC (Immunohistochemistry)
Positive Control
Stomach, Colon or esophagus.
Immunogen
Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
Cellular Localization
Cytoplasmic
Hu-chromosome Location
3q29
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using MUC4 Mouse Monoclonal Antibody (MUC4/3105) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using MUC4 Mouse Monoclonal Antibody (MUC4/3105) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified MUC4 Mouse Monoclonal Antibody (MUC4/3105). Confirmation of Purity and Integrity of Antibody.)
SDS_PAGE
(SDS-PAGE Analysis Purified MUC4 Mouse Monoclonal Antibody (MUC4/3105). Confirmation of Purity and Integrity of Antibody.)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC4 Mouse Monoclonal Antibody (MUC4/3105).)
References
Amatya VJ, et al. Mod Pathol, 2017 May.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
235kDa
NCBI Official Full Name
mucin-4 isoform a
NCBI Official Synonym Full Names
mucin 4, cell surface associated
NCBI Official Symbol
MUC4
NCBI Official Synonym Symbols
ASGP; MUC-4; HSA276359
NCBI Protein Information
mucin-4
UniProt Protein Name
Mucin-4
UniProt Gene Name
MUC4
UniProt Synonym Gene Names
MUC-4; ASGP; ASGP-1; ASGP-2
UniProt Entry Name
MUC4_HUMAN
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Product Notes
The MUC4 muc4 (Catalog #AAA215096) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MUC4 (Mucin 4/Gastric Mucin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MUC4 (Mucin 4/Gastric Mucin) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the MUC4 muc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUC4 (Mucin 4/Gastric Mucin), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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