Mouse Nav1.8 Monoclonal Antibody | anti-Scn10a antibody
Nav1.8 Antibody
Gene Names
Scn10a; PN3; Na(V)1.8
Reactivity
Human, Mouse, Rat, Monkey
Applications
Immunofluorescence, Immunocytochemistry, Immunohistochemistry, Western Blot
Purity
Protein G Purified
Synonyms
Nav1.8, Antibody; Nav1.8 Antibody; PN3; Na(V)1.8; Scn10a; anti-Scn10a antibody
Host
Mouse
Reactivity
Human, Mouse, Rat, Monkey
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
S134-12
Specificity
Detects ~220kDa. No cross reactivity against other Nav channels.
Purity/Purification
Protein G Purified
Form/Format
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration
1mg/mL (varies by lot)
Applicable Applications for anti-Scn10a antibody
AM (Antibody Microarray), IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot)
Certificate of Analysis
1 ug/mL of MBS800264 was sufficient for detection of Nav1.8 in 10ug of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Immunogen
Fusion protein amino acids 1724-1956 of rat Nav1.8.
Preparation and Storage
Ships on blue ice. Store at -20°C; 1 year+. Avoid freeze/thaw cycles.
Related Product Information for anti-Scn10a antibody
Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (3).
Product Categories/Family for anti-Scn10a antibody
References
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 4. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 5. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
sodium channel protein type 10 subunit alpha
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type X, alpha subunit
NCBI Official Symbol
Scn10a
NCBI Official Synonym Symbols
PN3; Na(V)1.8
NCBI Protein Information
sodium channel protein type 10 subunit alpha; sensory neuron sodium channel; peripheral nerve sodium channel 3; sodium channel type X alpha polypeptide; sodium channel protein type X subunit alpha; voltage-gated sodium channel subunit alpha Nav1.8; sodium channel voltage-gated type X alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide
UniProt Protein Name
Sodium channel protein type 10 subunit alpha
UniProt Gene Name
Scn10a
UniProt Synonym Gene Names
Sns; PN3
UniProt Entry Name
SCNAA_RAT
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Product Notes
The Scn10a scn10a (Catalog #AAA102859) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Nav1.8 Antibody reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's Nav1.8 can be used in a range of immunoassay formats including, but not limited to, AM (Antibody Microarray), IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the Scn10a scn10a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nav1.8, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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