Rabbit anti-Rat NXPH1 Monoclonal Antibody | anti-NXPH1 antibody

Recombinant Anti-NXPH1 Antibody, Rabbit Monoclonal

Cat. Num. AAA257294

• Reactivity: Rat
• Applications: Immunohistochemistry
• Purity: Protein A
• Synonyms: NXPH1, Antibody; Recombinant Anti-NXPH1 Antibody, Rabbit Monoclonal; Neurexophilin-1/NXPH1 Antibody, Rabbit MAb; neurexophilin 1; anti-NXPH1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 001
• Specificity: Rat Neurexophilin-1/NXPH1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-NXPH1 antibody: IHC (Immunohistochemistry)
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Rat Neurexophilin-1/NXPH1 protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Rat Neurexophilin-1/NXPH1 (rR Neurexophilin-1/NXPH1).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining of rat NXPH1 in rat brain with rabbit monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections).)

IHC (Immunohistochemistry)

(Immunochemical staining of rat NXPH1 in rat spinal cord with rabbit monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-NXPH1 antibody

Neurexophilin-1 or NXPH1 is a secreted glycoprotein, which belongs to the Neurexophilin family. The Neurexophilin family contains at least four genes and resembles a neuropeptide, suggesting a function as an endogenous ligand for alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Neurexophilin-1 constitutes a secreted cysteine-rich glycoprotein, forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins.

References

Missler M, et al. (1998) Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 273(52): 34716-23.Missler M, et al. (1998) Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci. 18(10): 3630-8.Petrenko AG, et al. (1996) Structure and evolution of neurexophilin. J Neurosci. 16(14): 4360-9.

NCBI and Uniprot Product Information

• NCBI GI #: 6981298
• NCBI GeneID: 25501
• NCBI Accession #: NP_037126.1
• NCBI GenBank Nucleotide #: NM_012994.2
• UniProt Accession #: Q63366; Q3KRD4
• Molecular Weight: 31,017 Da
• NCBI Official Full Name: neurexophilin-1
• NCBI Official Synonym Full Names: neurexophilin 1
• NCBI Official Symbol: Nxph1
• NCBI Protein Information: neurexophilin-1; neurophilin
• UniProt Protein Name: Neurexophilin-1
• UniProt Gene Name: Nxph1
• UniProt Synonym Gene Names: Nph1; Neurophilin
• UniProt Entry Name: NXPH1_RAT