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Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using PAPP-A Mouse Monoclonal Antibody (PAPPA/2715) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse anti-Human PAPP-A/Pappalysin-1 Monoclonal Antibody | anti-PAPP-A antibody
PAPP-A/Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus)
Gene Names
PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
Reactivity
Human
Applications
Immunohistochemistry
Purity
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Synonyms
PAPP-A/Pappalysin-1, Antibody; PAPP-A/Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus); ASBABP2; Aspecific BCL2 ARE binding protein 2; Differentially placenta 1 expressed protein; DIPLA1; IGF-dependent; IGFBP4ase; Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease); PAPA; PAPP A; PAPPA1; Pappalysin-1; Pregnancy Associated Plasma Protein A (PAPP-A); anti-PAPP-A antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b, kappa
Clone Number
PAPPA/2715
Specificity
Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
1627
Applicable Applications for anti-PAPP-A antibody
IHC (Immunohistochemistry)
Positive Control
Placenta.
Immunogen
Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
Cellular Localization
Secreted
Hu-chromosome Location
9q33.1
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using PAPP-A Mouse Monoclonal Antibody (PAPPA/2715) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using PAPP-A Mouse Monoclonal Antibody (PAPPA/2715) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS-PAGE
(SDS-PAGE Analysis Purified PAPP-A Mouse Monoclonal Antibody (PAPPA/2715). Confirmation of Purity and Integrity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified PAPP-A Mouse Monoclonal Antibody (PAPPA/2715). Confirmation of Purity and Integrity of Antibody.)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Placenta stained with PAPP-A Mouse Monoclonal Antibody (PAPPA/2715).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Placenta stained with PAPP-A Mouse Monoclonal Antibody (PAPPA/2715).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Placenta stained with PAPP-A Mouse Monoclonal Antibody (PAPPA/2715).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Placenta stained with PAPP-A Mouse Monoclonal Antibody (PAPPA/2715).)
References
Gururajan, P. (2012). Indian Heart Journal 64(2), 141-145
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
181kDa
NCBI Official Full Name
Pappalysin-1
NCBI Official Synonym Full Names
pappalysin 1
NCBI Official Symbol
PAPPA
NCBI Official Synonym Symbols
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
NCBI Protein Information
pappalysin-1
UniProt Protein Name
Pappalysin-1
UniProt Gene Name
PAPPA
UniProt Synonym Gene Names
IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A
UniProt Entry Name
PAPP1_HUMAN
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Product Notes
The PAPP-A pappa (Catalog #AAA215121) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PAPP-A/Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAPP-A/Pappalysin-1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PAPP-A pappa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAPP-A/Pappalysin-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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